Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC Pediatr. 2024 Aug 9;24(1):513. doi: 10.1186/s12887-023-04283-9.
The prevalence of celiac disease (CD) and hypothyroidism exhibit significant variation in different studies among patients with congenital heart disease (CHD). This study evaluated the frequency of laboratory test abnormalities in children and adolescents with CHD in Shiraz, Iran.
This prospective case-control study was conducted on 223 children and adolescents with CHD and healthy individuals referred to the heart clinic affiliated with Shiraz University of Medical Sciences between February 2019 and December 2021. They were classified into case and control groups. Blood tests were performed for total IgA antibody, anti-tissue transglutaminase IgA antibody (anti-TTG Ab), T4, and thyroid stimulating hormone (TSH) and anti-thyroid peroxidase antibodies in serum, along with transthoracic echocardiography. Likewise, demographic characteristics of patients, including age, sex, weight, height, and body mass index (BMI), were recorded. Also, anti-TTG Ab levels were compared among CHD patients according to cyanosis status, gender, age (above and below five years), and BMI (under and over 18.5).
Ninety-eight CHD patients and 100 healthy individuals with an average age of 5.32 ± 4.05 years (1-18 years) were examined. In children with CHD, atrial septal defect (27%), ventricular septal defect (20%), and tetralogy of Fallot (13%) were the most prevalent disorders. Only one CHD patient had an anti-TTG Ab level of 16.6 unit/mL, considered borderline for seropositive CD diagnosis. There was no difference in anti-TTG Ab levels between age (above and below five years), BMI (under and over 18.5), cyanosis status, and gender groups. Seven CHD patients had high TSH levels, three had cyanotic CHD, and one had Down syndrome. The TSH levels and non-autoimmune hypothyroidism were significantly higher in CHD patients than in normal subjects (p < 0.05).
According to the results of this study, the serum level of TSH and prevalence of non-autoimmune hypothyroidism were higher in patients with CHD than in normal subjects, but the serum level of anti-TTG Ab was not different between the two groups.
在患有先天性心脏病 (CHD) 的患者中，乳糜泻 (CD) 和甲状腺功能减退症的患病率在不同研究中存在显著差异。本研究评估了伊朗设拉子儿童和青少年 CHD 患者的实验室检查异常频率。
这是一项前瞻性病例对照研究，纳入了 2019 年 2 月至 2021 年 12 月期间在 Shiraz 大学医学科学附属医院心脏科就诊的 223 名 CHD 患儿和健康对照者。他们被分为病例组和对照组。检测血清中总 IgA 抗体、抗组织转谷氨酰胺酶 IgA 抗体（抗-TTG Ab）、T4 和促甲状腺激素（TSH）以及抗甲状腺过氧化物酶抗体，同时进行经胸超声心动图检查。同样，记录患者的人口统计学特征，包括年龄、性别、体重、身高和体重指数 (BMI)。此外，还根据发绀状态、性别、年龄（大于或小于 5 岁）和 BMI（小于或大于 18.5）比较 CHD 患者的抗-TTG Ab 水平。
共检查了 98 名 CHD 患者和 100 名健康对照者，平均年龄为 5.32±4.05 岁（1-18 岁）。在 CHD 患儿中，房间隔缺损（27%）、室间隔缺损（20%）和法洛四联症（13%）最为常见。仅有 1 名 CHD 患者的抗-TTG Ab 水平为 16.6 单位/毫升，考虑为血清阳性 CD 诊断的临界值。抗-TTG Ab 水平在年龄（大于或小于 5 岁）、BMI（小于或大于 18.5）、发绀状态和性别组之间无差异。7 名 CHD 患者的 TSH 水平升高，3 名患者患有发绀性 CHD，1 名患者患有唐氏综合征。CHD 患者的 TSH 水平和非自身免疫性甲状腺功能减退症明显高于正常对照组（p<0.05）。
根据本研究结果，与正常对照组相比，CHD 患者的血清 TSH 水平和非自身免疫性甲状腺功能减退症的患病率较高，但两组间抗-TTG Ab 水平无差异。
