Department of Clinical Sciences, Unit for Social Epidemiology, Lund University, Malmo, Sweden.
J Pediatr Gastroenterol Nutr. 2012 Dec;55(6):736-9. doi: 10.1097/MPG.0b013e318269f19d.
Previously, chromosomal anomalies and, to a lesser extent, other congenital anomalies have been associated with an increased risk of celiac disease (CD). We investigated these associations using a systematic approach. We identified all of the singleton children (792,401) born in Sweden between 1987 and 1993, and obtained cases of CD using the Swedish National Inpatient Registry. We applied Cox regression models as well as sibling designs to study the association between congenital anomalies and childhood CD. We observed that anomalies of face, neck, ear, heart, digestive tract, or chromosomes were associated with CD.
先前，染色体异常，以及在较小程度上，其他先天性异常与乳糜泻（CD）的风险增加有关。我们使用系统的方法研究了这些关联。我们确定了 1987 年至 1993 年期间在瑞典出生的所有单胎儿童（792,401 名），并使用瑞典国家住院患者登记处获取 CD 病例。我们应用 Cox 回归模型和同胞设计来研究先天性异常与儿童 CD 之间的关联。我们观察到，面部、颈部、耳朵、心脏、消化道或染色体异常与 CD 有关。
