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转录组分析揭示藜麦多糖抑制3T3-L1前脂肪细胞增殖的机制。

Transcriptome Analysis Reveals the Mechanism of Quinoa Polysaccharides Inhibiting 3T3-L1 Preadipocyte Proliferation.

作者信息

Teng Cong, Guo Shengyuan, Li Ying, Ren Guixing

机构信息

Institute of Agro-Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.

College of Food and Bioengineering, Chengdu University, Chengdu 610106, China.

出版信息

Foods. 2024 Jul 23;13(15):2311. doi: 10.3390/foods13152311.

DOI:10.3390/foods13152311
PMID:39123503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11311824/
Abstract

Quinoa is a highly nutritious and biologically active crop. Prior studies have demonstrated that quinoa polysaccharides exhibit anti-obesity activity. This investigation confirmed that quinoa polysaccharides have the ability to inhibit the growth of 3T3-L1 preadipocytes. The objective of transcriptome research was to investigate the mechanism of quinoa water-extracted polysaccharides and quinoa alkaline-extracted polysaccharides that hinder the growth of 3T3-L1 preadipocytes. There were 2194 genes that showed differential expression between untreated cells and those treated with high concentrations of quinoa water-extracted polysaccharides (QWPHs). There were 1774 genes that showed differential expression between untreated cells and those treated with high concentrations of quinoa alkaline-extracted polysaccharides (QAPHs). Through gene ontology and KEGG pathway analysis, 20 characteristic pathways are found significantly enriched between the untreated group and the QAPH and QWPH groups. These pathways include the NOD-like receptor, Hepatitis C, and the PI3K-Akt signaling pathway. Atp13A4 and Gbgt1 have been identified as genes that are upregulated and downregulated in both the untreated group and the QWPH group, as well as in the untreated group and the QAPH group. These findings establish a theoretical foundation for exploring quinoa polysaccharides as an anti-obesity agent.

摘要

藜麦是一种营养丰富且具有生物活性的作物。先前的研究表明，藜麦多糖具有抗肥胖活性。本研究证实，藜麦多糖具有抑制3T3-L1前脂肪细胞生长的能力。转录组研究的目的是探究藜麦水提多糖和藜麦碱提多糖阻碍3T3-L1前脂肪细胞生长的机制。在未处理细胞与用高浓度藜麦水提多糖（QWPHs）处理的细胞之间，有2194个基因表现出差异表达。在未处理细胞与用高浓度藜麦碱提多糖（QAPHs）处理的细胞之间，有1774个基因表现出差异表达。通过基因本体论和KEGG通路分析，发现未处理组与QAPH组和QWPH组之间有20条特征通路显著富集。这些通路包括NOD样受体、丙型肝炎和PI3K-Akt信号通路。Atp13A4和Gbgt1已被确定为在未处理组与QWPH组以及未处理组与QAPH组中均上调和下调的基因。这些发现为探索藜麦多糖作为抗肥胖剂奠定了理论基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/d13e01bc2648/foods-13-02311-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/a5caff1430d5/foods-13-02311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/7c0c83957c84/foods-13-02311-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/98d6e4cd515c/foods-13-02311-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/a8da0c1a6981/foods-13-02311-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/be647758fb5e/foods-13-02311-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/14eab07cdef8/foods-13-02311-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/06ca542ea8c2/foods-13-02311-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/8d7a5a7bf5d8/foods-13-02311-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/d13e01bc2648/foods-13-02311-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/a5caff1430d5/foods-13-02311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/7c0c83957c84/foods-13-02311-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/98d6e4cd515c/foods-13-02311-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/a8da0c1a6981/foods-13-02311-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/be647758fb5e/foods-13-02311-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/14eab07cdef8/foods-13-02311-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/06ca542ea8c2/foods-13-02311-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/8d7a5a7bf5d8/foods-13-02311-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8383/11311824/d13e01bc2648/foods-13-02311-g009.jpg

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