Spit Karlinde A, Azahaf Siham, de Blok Christel J M, Nanayakkara Prabath W B
Section General Internal Medicine, Department of Internal Medicine, Amsterdam Public Health Research Institute, Amsterdam University Medical Centres, Location VUmc, 1081 HZ Amsterdam, The Netherlands.
J Clin Med. 2024 Jul 27;13(15):4394. doi: 10.3390/jcm13154394.
: This study aims to describe a prospective clinical cohort of patients with silicone breast implants and suspected Breast Implant Illness (BII). : Women were included in a specialized silicone outpatient clinic at Amsterdam UMC, the Netherlands. Baseline characteristics were collected including medical history, implant details, and symptoms. Experienced physicians categorized BII suspicion as high, moderate, or low, based on symptoms and after exclusion of other probable causes. Additionally, participants completed questionnaires assessing symptoms and daily life impact at baseline, 6 months, 1, 2, and 5 years. For this initial analysis, the results from the first three years of inclusions were collected. : Data from 353 women were collected from December 2020-December 2023. At baseline, the most reported symptoms were fatigue, arthralgia, myalgia, and morning stiffness, accompanied by local symptoms in 83.3% of patients. At the clinic, 112 women were categorized as having high suspicion of BII, 147 women as moderate, and 94 women as low. At follow-up, 182 women (51.6%) opted for explantation. Following explantation, women with a high or moderate suspicion of BII experienced more significant symptom improvement, accompanied by a decrease in anxiety and a greater sense of control over their illness, compared to women with a low suspicion of BII. : Our study highlights a distinct interplay of systemic and local symptoms among women with suspicion of BII. Women with a high or moderate BII suspicion benefit significantly more from explantation than women with low suspicion. Experienced physicians are pivotal in effectively assessing and guiding this patient group, highlighting the need for tailored clinical approaches.
本研究旨在描述一组患有硅胶乳房植入物且疑似患有乳房植入物疾病（BII）的前瞻性临床队列患者。女性患者被纳入荷兰阿姆斯特丹大学医学中心的一家专门的硅胶门诊。收集了包括病史、植入物细节和症状在内的基线特征。经验丰富的医生根据症状并排除其他可能原因后，将BII疑似程度分为高、中、低三类。此外，参与者在基线、6个月、1年、2年和5年时完成了评估症状和对日常生活影响的问卷。对于本次初步分析，收集了纳入研究的前三年的结果。2020年12月至2023年12月收集了353名女性的数据。在基线时，最常报告的症状是疲劳、关节痛、肌痛和晨僵，83.3%的患者伴有局部症状。在诊所，112名女性被归类为高度疑似BII，147名女性为中度疑似，94名女性为低度疑似。在随访中，182名女性（51.6%）选择了取出植入物。取出植入物后，与低度疑似BII的女性相比，高度或中度疑似BII的女性症状改善更为显著，同时焦虑感降低，对疾病的控制感增强。我们的研究强调了疑似BII的女性中全身症状和局部症状之间存在明显的相互作用。高度或中度疑似BII的女性比低度疑似的女性从取出植入物中获益显著更多。经验丰富的医生在有效评估和指导这一患者群体方面至关重要，这突出了需要采用量身定制的临床方法。
