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孕妇精神药物治疗的进展:疗效、不良结局及治疗监测

Advances in Psychotropic Treatment for Pregnant Women: Efficacy, Adverse Outcomes, and Therapeutic Monitoring.

作者信息

Costa Bárbara, Vale Nuno

机构信息

PerMed Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.

CINTESIS@RISE, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.

出版信息

J Clin Med. 2024 Jul 27;13(15):4398. doi: 10.3390/jcm13154398.

Abstract

Advancements in psychotropic therapy for pregnant women are pivotal for addressing maternal mental health during the perinatal period. Screening for mood and anxiety symptoms during pregnancy is recommended to enable early intervention. Psychotropic medications, including antidepressants, benzodiazepines, antipsychotics, and mood stabilizers, are commonly used, but challenges remain regarding their safety and efficacy during pregnancy. Pregnancy induces significant changes in pharmacokinetics, necessitating personalized dosing strategies and careful monitoring. Real-time monitoring technologies, such as smartphone-integrated platforms and home-based monitoring, enhance accessibility and accuracy. Prospective studies and collaboration among healthcare providers are essential for evidence-based guidelines and optimal treatment strategies. Reducing stigma around mental health during pregnancy is crucial to ensure women seek help and discuss treatment options, promoting understanding and acceptance within the community.

摘要

孕妇精神药物治疗的进展对于解决围产期孕产妇心理健康问题至关重要。建议在孕期筛查情绪和焦虑症状,以便进行早期干预。常用的精神药物包括抗抑郁药、苯二氮䓬类药物、抗精神病药和心境稳定剂,但在孕期使用这些药物时,其安全性和有效性仍存在挑战。怀孕会引起药代动力学的显著变化,因此需要个性化的给药策略和仔细的监测。智能手机集成平台和家庭监测等实时监测技术提高了可及性和准确性。前瞻性研究以及医疗保健提供者之间的合作对于制定循证指南和优化治疗策略至关重要。减少孕期心理健康方面的污名化对于确保女性寻求帮助并讨论治疗方案、促进社区内的理解和接受至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b1/11312735/d970879f1561/jcm-13-04398-g001.jpg

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