D'Onghia Martina, Ciaffi Jacopo, Calabrese Laura, Tognetti Linda, Cinotti Elisa, Rubegni Pietro, Frediani Bruno, Ursini Francesco
Department of Medical, Surgical and Neurological Sciences, Dermatology Section, University of Siena, 53100 Siena, Italy.
Medicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
J Clin Med. 2024 Jul 27;13(15):4404. doi: 10.3390/jcm13154404.
Fibromyalgia is a complex multifaceted syndrome primarily characterised by chronic musculoskeletal pain, fatigue, and functional symptoms. Although FM is known to be associated with several comorbidities, the aim of this systematic review was to comprehensively examine the available evidence regarding the relationship between FM and dermatological manifestations. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and MedLine and Web of Science (WOS) databases were searched up to June 2023. After removing duplicate records, 21 articles were deemed eligible for inclusion in the qualitative synthesis. Overall, the included studies revealed an increased frequency of FM among patients with cutaneous diseases, including psoriasis, chronic urticaria, contact allergy, acneiform disorders, hidradenitis suppurativa, and vitiligo. Additionally, the presence of comorbid FM may intensify skin conditions, which has a negative impact on quality of life and vice versa. Although the causal mechanisms of FM are still far from being understood, this systematic review suggests a relationship between FM and skin disorders. However, further research is encouraged in this area.
纤维肌痛是一种复杂的多方面综合征，主要特征为慢性肌肉骨骼疼痛、疲劳和功能症状。尽管已知纤维肌痛与多种合并症相关，但本系统评价的目的是全面审查关于纤维肌痛与皮肤表现之间关系的现有证据。我们遵循系统评价和Meta分析的首选报告项目（PRISMA）指南，并检索了截至2023年6月的MedLine和科学网（WOS）数据库。在去除重复记录后，21篇文章被认为符合纳入定性合成的条件。总体而言，纳入的研究表明，在患有皮肤病的患者中，纤维肌痛的发病率有所增加，这些皮肤病包括银屑病、慢性荨麻疹、接触性过敏、痤疮样疾病、化脓性汗腺炎和白癜风。此外，合并纤维肌痛可能会加重皮肤状况，这对生活质量有负面影响，反之亦然。尽管纤维肌痛的因果机制仍远未明确，但本系统评价表明纤维肌痛与皮肤疾病之间存在关联。然而，鼓励在该领域进行进一步研究。
