Department of Toxicology and Food Science, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
School of Health and Medical Sciences, University of Economics and Human Sciences in Warsaw, Okopowa 59, 01-043 Warsaw, Poland.
Nutrients. 2024 Jul 26;16(15):2425. doi: 10.3390/nu16152425.
Food-drug interactions (FDIs) may alter drug pharmacokinetics and pharmacodynamics, modifying the whole therapy's effectiveness. Some of them cause the attenuation of drug effects, while others inhibit the medicines' metabolism resulting, in too high concentrations of the medicine in the body. Thus, some healthcare professionals-doctors, pharmacists or dieticians-should be aware of the possibility of food-drug interactions. This study aimed to assess knowledge of food-drug interactions among students of pharmacy, medicine, stomatology, medical analysis and dietetics and students of the college of further medical education for pharmacy technicians.
Students (n = 820) completed a custom-made questionnaire. The relationships between the continuous variables were analysed on the basis of Pearson's correlation coefficient. To verify the predictors of objective students' knowledge about food-drug interactions, a multiple linear regression model with analysis of covariance (ANCOVA) was used. The Kruskal-Wallis test was performed to compare the total scores the respondents received for questions assessing their objective knowledge of FDI.
Students' objective knowledge of FDIs correlated positively with their year of study and their self-evaluation of it. It was also significantly influenced by the field and mode of studies and by the fact that the issue had been discussed during the courses.
Most students of the medical university had serious deficiencies in their knowledge of food-drug interactions. This is of particular concern for future doctors and dentists. Among the respondents, pharmacy students stood out, as their FDI knowledge was greater. The issue of food-drug interactions should be more widely taught at medical universities, which was emphasised by the respondents themselves.
食物-药物相互作用（FDIs）可能改变药物的药代动力学和药效学，从而改变整个治疗的效果。其中一些会导致药物作用减弱，而另一些则会抑制药物代谢，导致体内药物浓度过高。因此，一些医疗保健专业人员——医生、药剂师或营养师——应该意识到食物-药物相互作用的可能性。本研究旨在评估药学、医学、口腔医学、医学分析和营养学专业的学生以及药剂师进修学院的学生对食物-药物相互作用的知识。
学生（n=820）填写了一份定制的问卷。基于 Pearson 相关系数分析了连续变量之间的关系。为了验证学生对食物-药物相互作用的客观知识的预测因素，采用了协方差分析（ANCOVA）的多元线性回归模型。采用 Kruskal-Wallis 检验比较了受访者对评估其对 FDI 的客观知识的问题的总得分。
学生对 FDIs 的客观知识与其学习年限和自我评估呈正相关。它还受到学习领域和模式以及课程中讨论该问题的事实的显著影响。
医科大学的大多数学生在食物-药物相互作用方面存在严重的知识缺陷。这对未来的医生和牙医来说尤其令人担忧。在受访者中，药学专业的学生表现突出，因为他们的 FDI 知识更丰富。受访者自己强调了在医科大学更广泛地教授食物-药物相互作用问题的重要性。
