Heart Failure and Respiratory Distress Clinic, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City 14080, Mexico.
Department of Epidemiological Information Analysis, General Directorate of Epidemiology, Mexico City 01480, Mexico.
Nutrients. 2024 Jul 30;16(15):2468. doi: 10.3390/nu16152468.
The most frequent body composition alterations in post-COVID-19 syndrome include low muscle mass, dynapenia, sarcopenia, and obesity. These conditions share interconnected pathophysiological mechanisms that exacerbate each other. The relationship between body composition phenotypes and metabolic abnormalities in post-COVID-19 syndrome remains unclear.
To evaluate the association between body composition phenotypes and insulin resistance (IR) and metabolic abnormalities in non-diabetic individuals with post-COVID-19 syndrome.
A cross-sectional, single-center study involving 483 subjects with post-COVID-19 syndrome following moderate to severe acute COVID-19 requiring hospitalization. Individuals with diabetes, those who declined to participate, or those who could not be contacted were excluded. Body composition phenotypes were classified as normal weight, dynapenia, sarcopenia, dynapenic obesity, and sarcopenic obesity (SO).
The average age was 52.69 ± 14.75 years; of note, 67.08% were male. The prevalence of body composition phenotypes was as follows: 13.25% were of normal weight, 9.52% had dynapenia, 9.94% had sarcopenia, 43.69% had obesity, 18.84% had dynapenic obesity, and 4.76% had SO. Additionally, 58.18% had IR. Obesity (OR: 2.98, CI95%; 1.64-5.41) and dynapenic obesity (OR: 4.98, CI95%; 1.46-6.88) were associated with IR.
The most common body composition phenotypes were obesity, dynapenic obesity, and dynapenia. Furthermore, obesity and dynapenic obesity were associated with IR in post-COVID-19 syndrome.
新冠病毒病（COVID-19）后最常见的身体成分改变包括肌肉量减少、无力、肌肉减少症和肥胖。这些情况具有相互关联的病理生理机制，会相互加重。新冠病毒病后综合征患者的身体成分表型与代谢异常之间的关系尚不清楚。
评估非糖尿病新冠病毒病后综合征患者的身体成分表型与胰岛素抵抗（IR）和代谢异常之间的关系。
这是一项横断面、单中心研究，共纳入 483 例因中重度急性 COVID-19 需要住院治疗的新冠病毒病后综合征患者。排除患有糖尿病、拒绝参与或无法联系的患者。将身体成分表型分为正常体重、无力、肌肉减少症、无力性肥胖和肌肉减少性肥胖（SO）。
患者的平均年龄为 52.69±14.75 岁，其中 67.08%为男性。身体成分表型的患病率如下：正常体重占 13.25%，无力占 9.52%，肌肉减少症占 9.94%，肥胖占 43.69%，无力性肥胖占 18.84%，SO 占 4.76%。此外，58.18%的患者存在 IR。肥胖（OR：2.98，95%CI：1.64-5.41）和无力性肥胖（OR：4.98，95%CI：1.46-6.88）与 IR 相关。
最常见的身体成分表型是肥胖、无力性肥胖和无力。此外，肥胖和无力性肥胖与新冠病毒病后综合征患者的 IR 相关。
