新冠后综合征住院患者的肌无力和肌少症与肺功能严重下降有关。

Dynapenia and Sarcopenia in Post-COVID-19 Syndrome Hospitalized Patients Are Associated with Severe Reduction in Pulmonary Function.

作者信息

Orea-Tejeda Arturo, Robles-Hernández Robinson, González-Islas Dulce, Jimenez-Gallardo Luz, Gochicoa-Rangel Laura, Castorena-Maldonado Armando, Hernández-Zenteno Rafael, Montañez-Orozco Alvaro, Valderrábano-Salas Benigno

机构信息

Heart Failure and Respiratory Distress Clinic, Cardiology Service, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City 14080, Mexico.

Department of Research in Tobacco Smoking and COPD at Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas" 2, Mexico City 14080, Mexico.

出版信息

J Clin Med. 2023 Oct 11;12(20):6466. doi: 10.3390/jcm12206466.

DOI:10.3390/jcm12206466

PMID:37892604

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10607104/

Abstract

BACKGROUND

After hospital discharge, post-COVID-19 syndrome has been observed to be associated with impaired diffusing capacity, respiratory muscle strength, and lung imaging abnormalities, in addition to loss of muscle mass/strength, sarcopenia, and obesity impact exercise tolerance, pulmonary functions, and overall prognosis. However, the relationship between lung function and the coexistence of obesity with low muscle strength and sarcopenia in post-COVID-19 patients remains poorly investigated. Therefore, our aim was to evaluate the association between lung function and the coexistence of obesity with dynapenia and sarcopenia in post-COVID-19 syndrome patients.

METHODS

This cross-sectional study included subjects who were hospitalized due to moderate to severe COVID-19, as confirmed by PCR testing. Subjects who could not be contacted, declined to participate, or died before the follow-up visit were excluded.

RESULTS

A total of 711 subjects were evaluated; the mean age was 53.64 ± 13.57 years, 12.4% had normal weight, 12.6% were dynapenic without obesity, 8.3% had sarcopenia, 41.6% had obesity, 21.2% had dynapenic obesity, and 3.8% had sarcopenic obesity. In terms of pulmonary function, the dynapenic subjects showed decreases of -3.45% in FEV, -12.61 cmH2O in MIP, and -12.85 cmH2O in MEP. On the other hand, the sarcopenic subjects showed decreases of -6.14 cmH2O in MIP and -11.64 cmH2O in MEP. The dynapenic obesity group displayed a reduction of -12.13% in PEF.

CONCLUSIONS

In post-COVID-19 syndrome, dynapenia and sarcopenia-both with and without obesity-have been associated with lower lung function.

摘要

背景

出院后，除了肌肉量/力量丧失、肌肉减少症和肥胖影响运动耐量、肺功能及总体预后外，还观察到新冠后综合征与弥散能力受损、呼吸肌力量及肺部影像异常有关。然而，新冠后患者肺功能与肥胖合并低肌肉力量和肌肉减少症之间的关系仍未得到充分研究。因此，我们的目的是评估新冠后综合征患者肺功能与肥胖合并肌无力和肌肉减少症之间的关联。

方法

这项横断面研究纳入了因中度至重度新冠而住院且经PCR检测确诊的受试者。无法联系、拒绝参与或在随访前死亡的受试者被排除。

结果

共评估了711名受试者；平均年龄为53.64±13.57岁，12.4%体重正常，12.6%为无肥胖的肌无力患者，8.3%有肌肉减少症，41.6%有肥胖症，21.2%有肌无力性肥胖，3.8%有肌少症性肥胖。在肺功能方面，肌无力受试者的第一秒用力呼气容积（FEV）下降了-3.45%，最大吸气压（MIP）下降了-12.61 cmH₂O，最大呼气压（MEP）下降了-12.85 cmH₂O。另一方面，肌肉减少症受试者的MIP下降了-6.14 cmH₂O，MEP下降了-11.64 cmH₂O。肌无力性肥胖组的呼气峰值流速（PEF）下降了-12.13%。