Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.
Department of General Mini-Invasive and Gastroenterological Surgery, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.
Nutrients. 2024 Aug 3;16(15):2551. doi: 10.3390/nu16152551.
Cholelithiasis is one of the more common complications following bariatric surgery. This may be related to the rapid weight loss during this period, although the exact mechanism of gallstone formation after bariatric surgery has not been fully elucidated.
The present literature review focuses on risk factors, prevention options and the impact of the gut microbiota on the development of gallbladder stones after bariatric surgery.
A potential risk factor for the development of cholelithiasis after bariatric surgery may be changes in the composition of the intestinal microbiota and bile acids. One of the bile acids-ursodeoxycholic acid-is considered to reduce the concentration of mucin proteins and thus contribute to reducing the formation of cholesterol crystals in patients with cholelithiasis. Additionally, it reduces the risk of both asymptomatic and symptomatic gallstones after bariatric surgery. Patients who developed gallstones after bariatric surgery had a higher abundance of and those who did not develop cholelithiasis had a higher abundance of and .
The exact mechanism of gallstone formation after bariatric surgery has not yet been clarified. Research suggests that the intestinal microbiota and bile acids may have an important role in this.
胆石症是肥胖症手术后较常见的并发症之一。这可能与该期间体重迅速下降有关，但肥胖症手术后胆石形成的确切机制尚未完全阐明。
本文献复习重点关注肥胖症手术后发生胆囊结石的危险因素、预防选择以及肠道微生物群的影响。
肥胖症手术后发生胆石症的一个潜在危险因素可能是肠道微生物群和胆汁酸组成的变化。一种胆汁酸——熊去氧胆酸，被认为可降低黏蛋白蛋白的浓度，从而有助于减少胆石症患者胆固醇晶体的形成。此外，它可降低肥胖症手术后无症状和有症状胆囊结石的风险。肥胖症手术后发生胆石症的患者中丰度较高，而未发生胆石症的患者中丰度较高。
肥胖症手术后胆石形成的确切机制尚未阐明。研究表明，肠道微生物群和胆汁酸可能在此过程中发挥重要作用。
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