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肝硬化组织中脂肪酸谱的改变及与 FA 代谢相关基因的表达。

Alterations of the Fatty Acid Profile and the Expression of Genes Related to FA Metabolism in Cirrhotic Liver Tissue.

机构信息

Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland.

Department of Environmental Analytics, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.

出版信息

Int J Mol Sci. 2024 Jul 25;25(15):8115. doi: 10.3390/ijms25158115.

DOI:10.3390/ijms25158115
PMID:39125684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11311876/
Abstract

In addition to direct damage to hepatocytes, long-term ethanol consumption leads to lipid accumulation and hepatic steatosis, as well as to the dysregulation of lipid metabolism. The final step in various liver diseases is cirrhosis. The aim of this study was to compare the FA (fatty acids) profile and expression levels of genes involved in lipid metabolism in cirrhotic liver tissue and normal liver tissue. Exploring the changes in the FA profile and expression of genes related to fatty acid metabolism in cirrhotic liver tissue reveals a molecular landscape that goes beyond the surface of traditional liver function assessments. Understanding the shifts in gene expression and fatty acid composition in liver tissue opens avenues for interventions that may aid in the treatment of cirrhosis in the future.

摘要

除了对肝细胞的直接损伤外，长期乙醇摄入还会导致脂肪堆积和肝脂肪变性，以及脂质代谢失调。各种肝病的最后阶段是肝硬化。本研究的目的是比较肝硬化肝组织和正常肝组织中脂肪酸（FA）谱和参与脂质代谢的基因的表达水平。探讨肝硬化肝组织中 FA 谱和脂肪酸代谢相关基因表达的变化，揭示了一个超越传统肝功能评估表面的分子图谱。了解肝组织中基因表达和脂肪酸组成的变化为未来可能有助于治疗肝硬化的干预措施开辟了道路。

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