普萘洛尔与美托洛尔治疗甲状腺功能亢进症的比较。
Comparison of propranolol and metoprolol in the management of hyperthyroidism.
作者信息
Murchison L E, How J, Bewsher P D
出版信息
Br J Clin Pharmacol. 1979 Dec;8(6):581-7. doi: 10.1111/j.1365-2125.1979.tb01048.x.
Abstract
1 Propranolol and metoprolol were both effective in controlling the symptoms and signs of hyperthyroidism. 2 Propranolol caused a highly significant increase in serum reverse T3 concentrations with lesser changes in other serum thyroid hormone levels, whereas metoprolol did not have this effect. 3 Steady-state plasma propranolol and metoprolol levels showed marked inter-individual variation. Metoprolol concentrations showed relatively little intra-individual variability, and could be related to the clinical efficacy of the drug, whereas no such relationship was demonstrated for propranolol.
摘要
- 普萘洛尔和美托洛尔在控制甲状腺功能亢进的症状和体征方面均有效。2. 普萘洛尔使血清反三碘甲状腺原氨酸浓度显著升高，而其他血清甲状腺激素水平变化较小，而美托洛尔没有这种作用。3. 稳态血浆普萘洛尔和美托洛尔水平显示出明显的个体间差异。美托洛尔浓度的个体内变异性相对较小，且可能与药物的临床疗效相关，而普萘洛尔未显示出这种关系。
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