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本文引用的文献

1
Statistical methods applied to the clinical diagnosis of thyrotoxicosis.应用于甲状腺毒症临床诊断的统计方法。
Q J Med. 1959 Apr;28(110):211-34.
2
Achilles-reflex recording with a simple photomotograph.使用简易光电记录器记录跟腱反射。
N Engl J Med. 1959 May 14;260(20):1027-8. doi: 10.1056/NEJM195905142602008.
3
A personality scale of manifest anxiety.一种显性焦虑人格量表。
J Abnorm Psychol. 1953 Apr;48(2):285-90. doi: 10.1037/h0056264.
4
Effect of beta-adrenergic blockade on finger tremor and Achilles reflex time in anxious and thyrotoxic patients.β-肾上腺素能阻滞剂对焦虑和甲状腺毒症患者手指震颤及跟腱反射时间的影响。
Acta Endocrinol (Copenh). 1968 Mar;57(3):353-62. doi: 10.1530/acta.0.0570353.
5
Plasma propranolol levels in adults with observations in four children.成人血浆普萘洛尔水平及对四名儿童的观察结果
Clin Pharmacol Ther. 1970 Jan-Feb;11(1):112-20. doi: 10.1002/cpt1970111112.
6
A comparison of three beta-adrenergic receptor-blocking drugs in thyrotoxic tachycardia.三种β-肾上腺素能受体阻滞剂治疗甲状腺功能亢进性心动过速的比较。
J Clin Pharmacol J New Drugs. 1968 Jul-Aug;8(4):268-71. doi: 10.1002/j.1552-4604.1968.tb00104.x.
7
Individualization of propranolol therapy.
Med Clin North Am. 1974 Sep;58(5):1063-9. doi: 10.1016/s0025-7125(16)32102-2.
8
A single method for measuring total thyroxine and free thyroxine index in serum.
J Nucl Med. 1973 Oct;14(10):740-6.
9
Effect of propranolol on serum-thyroxine.普萘洛尔对血清甲状腺素的影响。
Lancet. 1970 Oct 17;2(7677):829-30. doi: 10.1016/s0140-6736(70)91501-1.
10
Beta-adrenergic blockade in thyrotoxic myopathy.甲状腺毒症性肌病中的β-肾上腺素能阻滞剂
Lancet. 1968 Dec 7;2(7580):1219-20. doi: 10.1016/s0140-6736(68)91697-8.

普萘洛尔与美托洛尔治疗甲状腺功能亢进症的比较。

Comparison of propranolol and metoprolol in the management of hyperthyroidism.

作者信息

Murchison L E, How J, Bewsher P D

出版信息

Br J Clin Pharmacol. 1979 Dec;8(6):581-7. doi: 10.1111/j.1365-2125.1979.tb01048.x.

DOI:10.1111/j.1365-2125.1979.tb01048.x
PMID:391258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1429912/
Abstract

1 Propranolol and metoprolol were both effective in controlling the symptoms and signs of hyperthyroidism. 2 Propranolol caused a highly significant increase in serum reverse T3 concentrations with lesser changes in other serum thyroid hormone levels, whereas metoprolol did not have this effect. 3 Steady-state plasma propranolol and metoprolol levels showed marked inter-individual variation. Metoprolol concentrations showed relatively little intra-individual variability, and could be related to the clinical efficacy of the drug, whereas no such relationship was demonstrated for propranolol.

摘要
  1. 普萘洛尔和美托洛尔在控制甲状腺功能亢进的症状和体征方面均有效。2. 普萘洛尔使血清反三碘甲状腺原氨酸浓度显著升高，而其他血清甲状腺激素水平变化较小，而美托洛尔没有这种作用。3. 稳态血浆普萘洛尔和美托洛尔水平显示出明显的个体间差异。美托洛尔浓度的个体内变异性相对较小，且可能与药物的临床疗效相关，而普萘洛尔未显示出这种关系。