• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新型 N-乙烯基吡咯烷酮与丙烯酸和三乙二醇二甲基丙烯酸酯的两亲性三嵌段共聚物作为有前途的药物输送系统：设计、合成及体外生物学性质。

New Amphiphilic Terpolymers of N-Vinylpyrrolidone with Acrylic Acid and Triethylene Glycol Dimethacrylate as Promising Drug Delivery: Design, Synthesis and Biological Properties In Vitro.

机构信息

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia.

Institute of Microelectronics Technology and High-Purity Materials, Russian Academy of Sciences, 142432 Chernogolovka, Russia.

出版信息

Int J Mol Sci. 2024 Aug 1;25(15):8422. doi: 10.3390/ijms25158422.

DOI:10.3390/ijms25158422
PMID:39125990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11312434/
Abstract

The terpolymers of N-vinylpyrrolidone (VP) with acrylic acid and triethylene glycol methacrylate were synthesized with more than 90% yield by radical copolymerization in ethanol from monomeric mixtures of different molar composition (98:2:2, 95:5: 2 and 98:2:5) and their monomer composition, absolute molecular masses and hydrodynamic radii in aqueous media were determined. Using the MTT test, these terpolymers were established to be low toxic for non-tumor Vero cells and HeLa tumor cells. Polymer compositions of hydrophobic dye methyl pheophorbide a (MPP) based on studied terpolymers and linear polyvinylpyrrolidone (PVP) were obtained and characterized in water solution. Quantum-chemical modeling of the MPP-copolymer structures was conducted, and the possibility of hydrogen bond formation between terpolymer units and the MPP molecule was shown. Using fluorescence microscopy, the accumulation and distribution of polymer particles in non-tumor (FetMSC) and tumor (HeLa) cells was studied, and an increase in the accumulation of MPP with both types of particles was found.

摘要

N-乙烯基吡咯烷酮（VP）与丙烯酸和三乙二醇甲基丙烯酸酯的三元共聚物通过在乙醇中从不同摩尔组成的单体混合物（98:2:2、95:5:2 和 98:2:5）进行自由基共聚以超过 90%的产率合成，其单体组成、绝对分子量和水介质中的流体力学半径。使用 MTT 试验，这些三元共聚物被确定为对非肿瘤 Vero 细胞和 HeLa 肿瘤细胞低毒。以研究的三元共聚物和线性聚乙烯吡咯烷酮（PVP）为基础，得到了基于疏水染料甲氧基 pheophorbide a（MPP）的聚合物组成，并在水溶液中进行了表征。对 MPP-共聚物结构进行了量子化学建模，表明了共聚物单元与 MPP 分子之间形成氢键的可能性。通过荧光显微镜研究了聚合物颗粒在非肿瘤（FetMSC）和肿瘤（HeLa）细胞中的积累和分布，并发现两种类型的颗粒都增加了 MPP 的积累。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/adebb9a05506/ijms-25-08422-g026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/a4075e824ffc/ijms-25-08422-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/238e1449ccac/ijms-25-08422-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/30cc959e8368/ijms-25-08422-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/fc8d2455115f/ijms-25-08422-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/d2d608eb0b40/ijms-25-08422-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/7915b543bc88/ijms-25-08422-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/dfddeea50ece/ijms-25-08422-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/155c42567f50/ijms-25-08422-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/8808609240ab/ijms-25-08422-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/c11c57eb1322/ijms-25-08422-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/4d1bbcd46255/ijms-25-08422-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/259f746c759b/ijms-25-08422-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/4db75fe0aa90/ijms-25-08422-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/0bad495ab2e1/ijms-25-08422-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/55a79473d45b/ijms-25-08422-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/25306fb0e485/ijms-25-08422-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/010ce341bd6f/ijms-25-08422-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/c59f667482bd/ijms-25-08422-g018a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/129ecb8eef28/ijms-25-08422-g019a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/c600008b3ac9/ijms-25-08422-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/898c9be34221/ijms-25-08422-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/e8086cd2ba42/ijms-25-08422-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/0a7a59c3aa5d/ijms-25-08422-g023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/8df8af008f9a/ijms-25-08422-g024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/c090f2bfef19/ijms-25-08422-g025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/adebb9a05506/ijms-25-08422-g026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/a4075e824ffc/ijms-25-08422-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/238e1449ccac/ijms-25-08422-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/30cc959e8368/ijms-25-08422-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/fc8d2455115f/ijms-25-08422-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/d2d608eb0b40/ijms-25-08422-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/7915b543bc88/ijms-25-08422-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/dfddeea50ece/ijms-25-08422-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/155c42567f50/ijms-25-08422-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/8808609240ab/ijms-25-08422-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/c11c57eb1322/ijms-25-08422-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/4d1bbcd46255/ijms-25-08422-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/259f746c759b/ijms-25-08422-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/4db75fe0aa90/ijms-25-08422-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/0bad495ab2e1/ijms-25-08422-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/55a79473d45b/ijms-25-08422-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/25306fb0e485/ijms-25-08422-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/010ce341bd6f/ijms-25-08422-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/c59f667482bd/ijms-25-08422-g018a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/129ecb8eef28/ijms-25-08422-g019a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/c600008b3ac9/ijms-25-08422-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/898c9be34221/ijms-25-08422-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/e8086cd2ba42/ijms-25-08422-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/0a7a59c3aa5d/ijms-25-08422-g023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/8df8af008f9a/ijms-25-08422-g024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/c090f2bfef19/ijms-25-08422-g025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/876f/11312434/adebb9a05506/ijms-25-08422-g026.jpg

相似文献

1
New Amphiphilic Terpolymers of N-Vinylpyrrolidone with Acrylic Acid and Triethylene Glycol Dimethacrylate as Promising Drug Delivery: Design, Synthesis and Biological Properties In Vitro.新型 N-乙烯基吡咯烷酮与丙烯酸和三乙二醇二甲基丙烯酸酯的两亲性三嵌段共聚物作为有前途的药物输送系统：设计、合成及体外生物学性质。
Int J Mol Sci. 2024 Aug 1;25(15):8422. doi: 10.3390/ijms25158422.
2
Macromolecular Design and Engineering of New Amphiphilic -Vinylpyrrolidone Terpolymers for Biomedical Applications.用于生物医学应用的新型两亲性 - 乙烯基吡咯烷酮三元共聚物的大分子设计与工程。
Int J Mol Sci. 2023 Oct 14;24(20):15170. doi: 10.3390/ijms242015170.
3
New Nanosized Systems Doxorubicin-Amphiphilic Copolymers of -Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity.具有抗肿瘤活性的新型纳米系统——聚（乙烯基吡咯烷酮）与（二）甲基丙烯酸酯的阿霉素两亲共聚物
Pharmaceutics. 2022 Nov 23;14(12):2572. doi: 10.3390/pharmaceutics14122572.
4
Structure and State of Water in Branched -Vinylpyrrolidone Copolymers as Carriers of a Hydrophilic Biologically Active Compound.支化型乙烯基吡咯烷酮共聚物作为亲水性生物活性化合物载体的结构和状态。
Molecules. 2020 Dec 18;25(24):6015. doi: 10.3390/molecules25246015.
5
Mesoporous Networks of -Vinylpyrrolidone with (di)Methacrylates as Precursors of Ecological Molecular Imprinted Polymers.以（二）甲基丙烯酸酯为生态分子印迹聚合物前体的乙烯基吡咯烷酮介孔网络
Materials (Basel). 2021 Nov 9;14(22):6757. doi: 10.3390/ma14226757.
6
Cationic amphiphilic model networks based on symmetrical ABCBA pentablock terpolymers: synthesis, characterization, and modeling.基于对称ABCBA五嵌段三元共聚物的阳离子两亲性模型网络：合成、表征与建模
Biomacromolecules. 2007 May;8(5):1615-23. doi: 10.1021/bm0611477. Epub 2007 Apr 7.
7
Design and Investigation of New Water-Soluble Forms of α-Tocopherol with Antioxidant and Antiglycation Activity Using Amphiphilic Copolymers of -Vinylpyrrolidone.使用 N-乙烯基吡咯烷酮两亲共聚物设计和研究具有抗氧化和抗糖化活性的新型水溶性α-生育酚形式
Pharmaceutics. 2023 Apr 30;15(5):1388. doi: 10.3390/pharmaceutics15051388.
8
Facile access to cytocompatible multicompartment micelles with adjustable Janus-cores from A-block-B-graft-C terpolymers prepared by combination of ROP and ATRP.通过 ROP 和 ATRP 的结合制备 A 嵌段-B-接枝-C 三嵌段共聚物，可轻松获得具有可调性 Janus 核的细胞相容性多腔胶束。
Colloids Surf B Biointerfaces. 2014 Mar 1;115:302-9. doi: 10.1016/j.colsurfb.2013.12.026. Epub 2013 Dec 21.
9
Amphiphilic multiarm star block copolymer-based multifunctional unimolecular micelles for cancer targeted drug delivery and MR imaging.基于两亲性多臂星型嵌段共聚物的多功能单分子胶束用于癌症靶向药物递送和磁共振成像。
Biomaterials. 2011 Sep;32(27):6595-605. doi: 10.1016/j.biomaterials.2011.05.049. Epub 2011 Jun 12.
10
Preparation and recycling of aqueous two-phase systems with pH-sensitive amphiphilic terpolymer PADB.使用pH敏感型两亲性三元共聚物PADB制备及循环利用双水相体系
Biotechnol Prog. 2009 May-Jun;25(3):820-4. doi: 10.1002/btpr.146.

本文引用的文献

1
Macromolecular Design and Engineering of New Amphiphilic -Vinylpyrrolidone Terpolymers for Biomedical Applications.用于生物医学应用的新型两亲性 - 乙烯基吡咯烷酮三元共聚物的大分子设计与工程。
Int J Mol Sci. 2023 Oct 14;24(20):15170. doi: 10.3390/ijms242015170.
2
Hyperbranched Copolymers of Methacrylic Acid and Lauryl Methacrylate H-P(MAA-co-LMA): Synthetic Aspects and Interactions with Biorelevant Compounds.甲基丙烯酸与甲基丙烯酸月桂酯的超支化共聚物H-P(MAA-co-LMA)：合成方面及其与生物相关化合物的相互作用
Pharmaceutics. 2023 Apr 9;15(4):1198. doi: 10.3390/pharmaceutics15041198.
3
Nanoparticles of -Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity.
乙烯基吡咯烷酮两亲共聚物与脱镁叶绿酸的纳米颗粒作为光动力疗法中有前景的光敏剂：设计、性质及体外光毒性活性
Pharmaceutics. 2023 Jan 12;15(1):273. doi: 10.3390/pharmaceutics15010273.
4
New Nanosized Systems Doxorubicin-Amphiphilic Copolymers of -Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity.具有抗肿瘤活性的新型纳米系统——聚（乙烯基吡咯烷酮）与（二）甲基丙烯酸酯的阿霉素两亲共聚物
Pharmaceutics. 2022 Nov 23;14(12):2572. doi: 10.3390/pharmaceutics14122572.
5
Structure and State of Water in Branched -Vinylpyrrolidone Copolymers as Carriers of a Hydrophilic Biologically Active Compound.支化型乙烯基吡咯烷酮共聚物作为亲水性生物活性化合物载体的结构和状态。
Molecules. 2020 Dec 18;25(24):6015. doi: 10.3390/molecules25246015.
6
Miktoarm Star Polymers: Branched Architectures in Drug Delivery.杂臂星形聚合物：药物递送中的支化结构
Pharmaceutics. 2020 Aug 30;12(9):827. doi: 10.3390/pharmaceutics12090827.
7
Smart Targeting To Improve Cancer Therapeutics.智能靶向以改善癌症治疗
Drug Des Devel Ther. 2019 Oct 30;13:3753-3772. doi: 10.2147/DDDT.S219489. eCollection 2019.
8
Encapsulation of anticancer drug doxorubicin inside dendritic macromolecular cavities: First-principles benchmarks.将抗癌药物阿霉素封装在树枝状大分子腔室内：第一性原理基准。
Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jun 15;217:278-287. doi: 10.1016/j.saa.2019.03.083. Epub 2019 Mar 25.
9
Unique Features of Metformin: A Combined Experimental, Theoretical, and Simulation Study of Its Structure, Dynamics, and Interaction Energetics with DNA Grooves.二甲双胍的独特特征：结构、动力学及其与 DNA 凹槽相互作用能的实验、理论和模拟综合研究。
J Phys Chem B. 2018 Mar 1;122(8):2227-2242. doi: 10.1021/acs.jpcb.7b11928. Epub 2018 Feb 15.
10
Molecular dynamics simulation of coarse-grained poly(L-lysine) dendrimers.粗粒度聚（L-赖氨酸）树枝状大分子的分子动力学模拟
J Mol Model. 2016 Mar;22(3):59. doi: 10.1007/s00894-016-2925-0. Epub 2016 Feb 17.