Kurmaz Svetlana V, Fadeeva Natalia V, Gorshkova Anna I, Kurochkin Sergey A, Knerelman Eugenia I, Davydova Galina I, Torbov Vladimir I, Dremova Nadezhda N, Konev Dmitry V, Kurmaz Vladimir A, Ignatiev Vladislav M, Emelyanova Nina S
Institute of Problems of Chemical Physics, Russian Academy of Sciences, Prosp. Akad. Semenova 1, 142432 Chernogolovka, Russia.
Department of Fundamental Physical and Chemical Engineering, M.V. Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
Materials (Basel). 2021 Nov 9;14(22):6757. doi: 10.3390/ma14226757.
Mesoporous polymer networks were prepared via the cross-linking radical copolymerization of non-toxic hydrophilic -vinylpyrrolidone (VP) with triethylene glycol dimethacrylate (TEGDM) and poly(ethylene glycol) methyl ester methacrylate (PEGMMA) in bulk, using appropriate soluble and thermodynamically compatible macromolecular additives with a branched structure as porogens. The branched copolymers of various monomer compositions were obtained by radical copolymerization in toluene, controlled by 1-decanethiol, and these materials were characterized by a wide set of physical chemical methods. The specific surface areas and surface morphology of the polymer networks were determined by nitrogen low-temperature adsorption or Rose Bengal (RB) sorption, depending on the copolymer compositions and scanning electron microscopy. The electrochemical properties of RB before and after its encapsulation into a branched VP copolymer were studied on a glassy carbon electrode and the interaction between these substances was observed. Quantum chemical modeling of RB-VP or RB-copolymer complexes has been carried out and sufficiently strong hydrogen bonds were found in these systems. The experimental and modeling data demonstrate the high potency of such mesoporous polymer networks as precursors of molecularly imprinted polymers for the recognition of fluorescent dyes as nanomarkers for biomedical practice.
通过无毒亲水性乙烯基吡咯烷酮（VP）与三乙二醇二甲基丙烯酸酯（TEGDM）和聚（乙二醇）甲基丙烯酸甲酯（PEGMMA）在本体中进行交联自由基共聚，使用具有支化结构的适当可溶性且热力学相容的大分子添加剂作为致孔剂，制备了介孔聚合物网络。通过在甲苯中由1 - 癸硫醇控制的自由基共聚获得了各种单体组成的支化共聚物，并用多种物理化学方法对这些材料进行了表征。根据共聚物组成和扫描电子显微镜，通过氮气低温吸附或玫瑰红（RB）吸附来测定聚合物网络的比表面积和表面形态。在玻碳电极上研究了RB封装到支化VP共聚物前后的电化学性质，并观察了这些物质之间的相互作用。对RB - VP或RB - 共聚物复合物进行了量子化学建模，发现这些体系中存在足够强的氢键。实验和建模数据表明，这种介孔聚合物网络作为分子印迹聚合物的前体，对于识别作为生物医学实践纳米标记物的荧光染料具有很高的潜力。
