Mempel E, Rap Z, Jurkiewicz J, Kuciński L
Neurol Neurochir Pol. 1985 Jul-Aug;19(4):327-32.
The authors report results of surgical treatment of 30 patients treated by cryohypophysectomy by the stereotactic method through the nose and sphenoid sinus in the years 1967-1979. The material included 28 cases of acromegaly and 2 cases of gigantism. The pathological manifestations in acromegaly and gigantism were analysed for demonstration which of them can regress after surgical treatment. The results of hormonal determinations, particularly the levels of growth hormone, 17-KS and hydroxysteroids, as well as blood glucose curves, were compared before and after cryohypophysectomy and their normalization was observed after the operation. There was principally no need for substitutive treatment after surgical treatment with the exception of 4 cases in which this treatment was given during several postoperative months. The indications to this method of therapy include cases of acromegaly and gigantism with presence of active intrasellar adenomas. Patients should be referred for treatment early before development of skeletal deformities.
作者报告了1967年至1979年间采用立体定向经鼻蝶窦冷冻垂体切除术治疗的30例患者的手术治疗结果。该材料包括28例肢端肥大症和2例巨人症。对肢端肥大症和巨人症的病理表现进行了分析，以证明其中哪些在手术治疗后可以消退。比较了冷冻垂体切除术前和术后的激素测定结果，特别是生长激素、17 - KS和羟类固醇水平，以及血糖曲线，并观察到术后这些指标恢复正常。手术治疗后，除4例在术后数月内进行了替代治疗外，原则上无需进行替代治疗。这种治疗方法的适应症包括伴有鞍内活动性腺瘤的肢端肥大症和巨人症病例。患者应在骨骼畸形发展之前尽早转诊接受治疗。
