DiTullio M V, Rand R W
J Neurosurg. 1977 Jan;46(1):1-11. doi: 10.3171/jns.1977.46.1.0001.
Between 1963 and 1974, 54 patients with acromegaly (28 men and 26 women) ranging in age from 23 to 61 years were evaluated. Each patient underwent thorough preperative neurological, roentgenographic, and endocrinological surveys; most demonstrated mild-to-severe abnormalities in growth hormone immunoassay and oral glucose tolerance. Of those who underwent stereotaxic cryohypophysectomy, approximately 80% were considered to have a beneficial result. The efficacy of this form of therapy was judged on the basis of: 1) significant overall clinical improvement and regression of acromegalic features; 2) improvement in the glucose tolerance curve; and 3) a fall of serum growth hormone below 10 ng/ml. Complications including rhinorrhea, meningitis, and hemorrhage occurred in only a small number of cases. A comparison is made between this technique and other, including craniotomy, radiotherapy, and transnasal transsphenoidal hypophysectomy. The efficacy, low morbidity, and the ease with which the procedure may be performed make this our treatment of choice when dealing with growth-hormone-producing pituitary adenomas with no suprasellar extension.
1963年至1974年间，对54例肢端肥大症患者（28名男性和26名女性）进行了评估，年龄在23至61岁之间。每位患者都接受了全面的术前神经学、放射学和内分泌学检查；大多数患者在生长激素免疫测定和口服葡萄糖耐量试验中表现出轻度至重度异常。在接受立体定向冷冻垂体切除术的患者中，约80%被认为治疗效果良好。这种治疗方式的疗效依据以下几点判断：1）整体临床显著改善和肢端肥大症特征消退；2）葡萄糖耐量曲线改善；3）血清生长激素降至10 ng/ml以下。并发症包括鼻漏、脑膜炎和出血，仅发生在少数病例中。将该技术与其他技术（包括开颅手术、放射治疗和经鼻经蝶窦垂体切除术）进行了比较。该技术疗效好、发病率低且操作简便，使其成为治疗无鞍上扩展的分泌生长激素的垂体腺瘤的首选治疗方法。
