Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Division of Geriatrics, Department of Internal Medicine, Istanbul Medical School, Istanbul University, Istanbul, Türkiye.
Nutrition. 2024 Oct;126:112518. doi: 10.1016/j.nut.2024.112518. Epub 2024 Jun 12.
Cardiac diastolic dysfunction (left ventricular diastolic dysfunction [LVDD]) is a well-known predictor of heart failure. We hypothesized that sarcopenia is independently associated with diastolic dysfunction. We aimed to investigate the association of the most recent consensus definition of sarcopenia with LVDD.
We included 121 older participants admitted to a cardiology outpatient clinic. We followed the European Working Group on Sarcopenia in Older People 2 definition of confirmed sarcopenia (presence of low muscle mass and low muscle strength). We estimated skeletal muscle mass with bioimpedance analysis and muscle strength by hand grip strength via a Jamar hydraulic hand dynamometer. Skeletal muscle mass was adjusted by body mass index. LVDD was determined by echocardiographic parameters measured per American Society of Echocardiography recommendations. We ran multivariate logistic regression analyses adjusted for well-known risk factors for diastolic dysfunction (i.e., age, sex, obesity, smoking, diabetes mellitus, hypertension, and ischemic heart disease) to detect whether sarcopenia was independently associated with diastolic dysfunction. We gave results in odds ratio (OR) and 95% confidence interval (CI).
Mean age was 69.9 ± 5.8 years, and 38.8% of participants were male. Confirmed sarcopenia was detected in 34.7%, and diastolic dysfunction was detected in 19.8%. In univariate analyses, sarcopenia was associated with diastolic dysfunction (OR, 6.7, 95% CI, 2.4-18.9). Regression analyses showed that two parameters, sarcopenia (OR, 7.4, 95% CI, 2.1-26.6, P = 0.002) and obesity (OR, 5.0, 95% CI, 1.03-24.6, P = 0.046), were associated with diastolic dysfunction.
This study revealed sarcopenia to be a new risk factor for diastolic dysfunction, adding to its known risk factors. Future longitudinal studies are needed to clarify the factors underlying their copresence.
心脏舒张功能障碍（左心室舒张功能障碍[LVDD]）是心力衰竭的一个已知预测因子。我们假设，肌肉减少症与舒张功能障碍独立相关。我们旨在研究最新的肌肉减少症共识定义与 LVDD 的相关性。
我们纳入了 121 名因心脏问题到心内科门诊就诊的老年人。我们遵循欧洲老年人肌肉减少症工作组 2 （EWGSOP2）的定义来确认肌肉减少症（存在低肌肉量和低肌肉力量）。我们使用生物阻抗分析法来估计骨骼肌质量，并使用 Jamar 液压测力计对手握力进行测量来评估肌肉力量。我们通过体质量指数对骨骼肌质量进行了调整。LVDD 通过美国超声心动图学会推荐的超声心动图参数来确定。我们进行了多变量逻辑回归分析，调整了舒张功能障碍的已知危险因素（即年龄、性别、肥胖、吸烟、糖尿病、高血压和缺血性心脏病），以检测肌肉减少症是否与舒张功能障碍独立相关。我们以比值比（OR）和 95%置信区间（CI）报告结果。
参与者的平均年龄为 69.9±5.8 岁，38.8%为男性。34.7%的参与者被确诊为肌肉减少症，19.8%的参与者存在舒张功能障碍。在单变量分析中，肌肉减少症与舒张功能障碍相关（OR，6.7，95%CI，2.4-18.9）。回归分析显示，两个参数，即肌肉减少症（OR，7.4，95%CI，2.1-26.6，P=0.002）和肥胖（OR，5.0，95%CI，1.03-24.6，P=0.046）与舒张功能障碍相关。
这项研究表明，肌肉减少症是舒张功能障碍的一个新的危险因素，增加了其已知的危险因素。未来需要进行纵向研究，以阐明它们共同存在的潜在因素。
