School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia; Center for Genomics and Personalised Health, Translational Research Institute, Queensland University of Technology, Brisbane, Australia.
School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia; Center for Genomics and Personalised Health, Translational Research Institute, Queensland University of Technology, Brisbane, Australia; ARC Training Centre for Cell & Tissue Engineering Technologies, Brisbane, Australia.
Cancer Lett. 2024 Sep 28;600:217156. doi: 10.1016/j.canlet.2024.217156. Epub 2024 Aug 8.
Cancer cells display an altered metabolic phenotype, characterised by increased glycolysis and lactate production, even in the presence of sufficient oxygen - a phenomenon known as the Warburg effect. This metabolic reprogramming is a crucial adaptation that enables cancer cells to meet their elevated energy and biosynthetic demands. Importantly, the tumor microenvironment plays a pivotal role in shaping and sustaining this metabolic shift in cancer cells. This review explores the intricate relationship between the tumor microenvironment and the Warburg effect, highlighting how communication within this niche regulates cancer cell metabolism and impacts tumor progression and therapeutic resistance. We discuss the potential of targeting the Warburg effect as a promising therapeutic strategy, with the aim of disrupting the metabolic advantage of cancer cells and enhancing our understanding of this complex interplay within the tumor microenvironment.
癌细胞表现出改变的代谢表型，其特征为即使在有足够氧气的情况下，糖酵解和乳酸生成也增加，这一现象被称为沃伯格效应。这种代谢重编程是一种关键的适应，使癌细胞能够满足其升高的能量和生物合成需求。重要的是，肿瘤微环境在塑造和维持癌细胞的这种代谢转变中起着关键作用。这篇综述探讨了肿瘤微环境与沃伯格效应之间的复杂关系，强调了在这个小生境中的交流如何调节癌细胞代谢，并影响肿瘤进展和治疗耐药性。我们讨论了将沃伯格效应作为一种有前途的治疗策略的潜力，旨在破坏癌细胞的代谢优势，并增强我们对肿瘤微环境中这种复杂相互作用的理解。
