Aiello Francesco, Gallo Afflitto Gabriele, Ceccarelli Francesca, Turco Maria Vittoria, Han Yuyi, Amescua Guillermo, Dart John K, Nucci Carlo
Ophthalmology Unit, Department of Experimental Medicine, Università di Roma "Tor Vergata," Rome, Italy.
Ophthalmology Unit, Department of Experimental Medicine, Università di Roma "Tor Vergata," Rome, Italy; Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.
Ophthalmology. 2025 Feb;132(2):206-218. doi: 10.1016/j.ophtha.2024.08.003. Epub 2024 Aug 9.
To provide an overview on the incidence of Acanthamoeba keratitis (AK).
Although being a sight-threatening cause of infectious keratitis, a comprehensive assessment of the incidence of AK is lacking.
Incidence of AK was computed as the number of eyes with AK per health care center, per year (annualized center incidence [ACI]). Two meta-analytical ratios also were calculated: (1) the ratio of eyes with AK to the count of eyes with nonviral microbial keratitis (MK) and (2) the ratio of eyes with AK to the overall population (i.e., the total number of people in a nation or region, as indicated by the authors in each study). Center was defined as the health care facility where the study took place. Actual and projected estimates of the number of eyes with AK in years were calculated multiplying the ratio of eyes with AK to the total population and the corresponding population estimates, sourced from the United Nations Population Prospects.
Overall, 105 articles were included, published between 1987 and 2022. The total number of eyes identified was 91 951, with 5660 eyes affected by AK and 86 291 eyes affected by nonviral MK. The median ACI was 1.9 eyes with AK per health care center per year (95% confidence interval [CI], 1.5-2.6 eyes), with no statistically significant differences among continents. The ratio of eyes with AK to the total number of eyes with MK was 1.52% (95% CI, 1.03%-2.22%), whereas the ratio of eyes with AK in relationship to the entire population was estimated at 2.34 eyes per 1 000 000 people (95% CI, 0.98-5.55 per 1 000 000 people). The projected increase in the numbers of eyes with AK indicated an increase of 18.5% (n = 15 355 eyes with AK) in 2053 and 25.5% (n = 16 253 eyes with AK) in 2073, compared with the baseline of 2023 (n = 12 953 eyes with AK).
Acanthamoeba keratitis emerged as a relatively low-incident disorder, and no significant differences in terms of its incidence were found among different continents.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
概述棘阿米巴角膜炎（AK）的发病率。
尽管AK是一种威胁视力的感染性角膜炎病因，但目前缺乏对其发病率的全面评估。
AK发病率的计算方式为每个医疗保健中心每年患AK的眼数（年度中心发病率[ACI]）。还计算了两个荟萃分析比率：（1）患AK的眼数与非病毒性微生物性角膜炎（MK）患眼数之比；（2）患AK的眼数与总人口数之比（即每项研究作者所指出的一个国家或地区的总人数）。中心定义为开展研究的医疗保健机构。通过将患AK的眼数与总人口数之比乘以相应的人口估计数（源自《联合国人口展望》），计算出各年份患AK眼数的实际和预测估计值。
总体而言，纳入了1987年至2022年期间发表的105篇文章。确定的患眼总数为91951只，其中5660只眼患AK，86291只眼患非病毒性MK。ACI中位数为每个医疗保健中心每年1.9只患AK的眼（95%置信区间[CI]，1.5 - 2.6只眼），各大洲之间无统计学显著差异。患AK的眼数与患MK的眼总数之比为1.52%（95%CI，1.03% - 2.22%），而患AK的眼数与整个人口数之比估计为每100万人中有2.34只眼（95%CI，每100万人中0.98 - 5.55只眼）。与2023年的基线（12953只患AK的眼）相比，预计患AK的眼数将增加，2053年增加18.5%（n = 15355只患AK的眼），2073年增加25.5%（n = 16253只患AK的眼）。
棘阿米巴角膜炎是一种发病率相对较低的疾病，不同大洲在发病率方面未发现显著差异。
在本文末尾的脚注和披露中可能会找到专有或商业披露信息。
