Department of Orthopedic Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, P.R. China; Bioinspired Engineering and Biomechanics Center (BEBC), Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China.
Bioinspired Engineering and Biomechanics Center (BEBC), Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China; TFX Group-Xi'an Jiaotong University Institute of Life Health, Xi'an 710049, P.R. China.
Trends Cancer. 2024 Sep;10(9):792-808. doi: 10.1016/j.trecan.2024.07.003. Epub 2024 Aug 10.
Many tumors prefer to metastasize to bone, but the underlying mechanisms remain elusive. The human skeletal system has unique physical properties, that are distinct from other organs, which play a key role in directing the behavior of tumor cells within bone. Understanding the physical journey of tumor cells within bone is crucial. In this review we discuss bone metastasis in the context of how physical cues in the bone vasculature and bone marrow niche regulate the fate of tumor cells. Our objective is to inspire innovative diagnostic and therapeutic approaches for bone metastasis from a mechanobiological perspective.
许多肿瘤更倾向于转移到骨骼，但潜在的机制仍难以捉摸。人体骨骼系统具有独特的物理特性，与其他器官明显不同，这些特性在指导肿瘤细胞在骨骼中的行为方面起着关键作用。了解肿瘤细胞在骨骼中的物理迁移过程至关重要。在这篇综述中，我们讨论了骨骼转移的情况，以及骨骼血管和骨髓微环境中的物理线索如何调节肿瘤细胞的命运。我们的目标是从机械生物学的角度为骨骼转移激发创新的诊断和治疗方法。
