Mahapatra Chitaranjan, Kishore Arnaw, Gawad Jineetkumar, Al-Emam Ahmed, Kouzeiha Riad Azzam, Rusho Maher Ali
Paris Saclay Institute of Neuroscience, Paris Saclay University, Saclay, France.
Microbiology and Immunology, Xavier University School of Medicine, Aruba, Netherlands.
Front Physiol. 2025 Mar 5;16:1536165. doi: 10.3389/fphys.2025.1536165. eCollection 2025.
The transformation of normal breast cells into cancerous cells is a complex process influenced by both genetic and microenvironmental factors. Recent studies highlight the significant role of membrane potential (Vm) alterations in this transformation. Cancer cells typically exhibit a depolarized resting membrane potential (RMP) compared to normal cells, which correlates with increased cellular activity and more aggressive cancer behavior. These RMP and Vm changes are associated with altered ion channel activity, altered calcium dynamics, mitochondrial dysfunction, modified gap junction communication, and disrupted signaling pathways. Such fluctuations in RMP and Vm influence key processes in cancer progression, including cell proliferation, migration, and invasion. Notably, more aggressive subtypes of breast cancer cells display more frequent and pronounced Vm fluctuations. Understanding the electrical properties of cancer cells provides new insights into their behavior and offers potential therapeutic targets, such as ion channels and Vm regulation. This review synthesizes current research on how various factors modulate membrane potential and proposes an electrophysiological model of breast cancer cells based on experimental and clinical data from the literature. These findings may pave the way for novel pharmacological targets for clinicians, researchers, and pharmacologists in treating breast cancer.
正常乳腺细胞转变为癌细胞是一个受遗传和微环境因素影响的复杂过程。最近的研究突出了膜电位（Vm）改变在这一转变过程中的重要作用。与正常细胞相比，癌细胞通常表现出静息膜电位（RMP）去极化，这与细胞活性增加和更具侵袭性的癌症行为相关。这些RMP和Vm的变化与离子通道活性改变、钙动力学改变、线粒体功能障碍、间隙连接通讯改变以及信号通路中断有关。RMP和Vm的这种波动影响癌症进展中的关键过程，包括细胞增殖、迁移和侵袭。值得注意的是，更具侵袭性的乳腺癌细胞亚型表现出更频繁、更明显的Vm波动。了解癌细胞的电特性为深入了解其行为提供了新的视角，并提供了潜在的治疗靶点，如离子通道和Vm调节。这篇综述综合了当前关于各种因素如何调节膜电位的研究，并根据文献中的实验和临床数据提出了乳腺癌细胞的电生理模型。这些发现可能为临床医生、研究人员和药理学家治疗乳腺癌提供新的药理学靶点。
