Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.
N. N. Pet-rov National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
Bull Exp Biol Med. 2024 Jul;177(3):323-327. doi: 10.1007/s10517-024-06182-0. Epub 2024 Aug 11.
In vivo antigenotoxic activity of BP-C2 composition (at doses of 60, 80, and 120 mg/kg) based on polyphenolic compounds derived from hydrolyzed lignin was evaluated in mouse germ cells. The BP-C2 composition dose-dependently reduced the aneugenic activity of topoisomerase II inhibitor etoposide in mouse oocytes without affecting the clastogenic activity of the genotoxicant. In mouse testicular cells, the BP-C2 composition reduced the DNA-damaging activity of the pro-oxidant genotoxicant dioxidine, but not etoposide. The cytoprotective activity of BP-C2 composition was revealed in relation to etoposide-induced cytotoxicity.
基于水解木质素衍生的多酚化合物的 BP-C2 组合物（剂量为 60、80 和 120mg/kg）的体内抗原毒性活性在小鼠生殖细胞中进行了评估。BP-C2 组合物剂量依赖性地降低了拓扑异构酶 II 抑制剂依托泊苷在小鼠卵母细胞中的变构活性，而不影响遗传毒物的断裂活性。在小鼠睾丸细胞中，BP-C2 组合物降低了促氧化剂遗传毒物二恶烷的 DNA 损伤活性，但不降低依托泊苷。BP-C2 组合物的细胞保护活性与依托泊苷诱导的细胞毒性有关。
