Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Translational Research Centre in Onco-haematology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Bioessays. 2024 Oct;46(10):e2400048. doi: 10.1002/bies.202400048. Epub 2024 Aug 11.
The accuracy of cell division requires precise regulation of the cellular machinery governing DNA/genome duplication, ensuring its equal distribution among the daughter cells. The control of the centrosome cycle is crucial for the formation of a bipolar spindle, ensuring error-free segregation of the genome. The cell and centrosome cycles operate in close synchrony along similar principles. Both require a single duplication round in every cell cycle, and both are controlled by the activity of key protein kinases. Nevertheless, our comprehension of the precise cellular mechanisms and critical regulators synchronizing these two cycles remains poorly defined. Here, we present our hypothesis that the spatiotemporal regulation of a dynamic equilibrium of mitotic kinases activities forms a molecular clock that governs the synchronous progression of both the cell and the centrosome cycles.
细胞分裂的准确性需要精确调节控制 DNA/基因组复制的细胞机制，以确保其在子细胞中均等分配。中心体周期的控制对于形成双极纺锤体至关重要，可确保基因组的无差错分离。细胞周期和中心体周期按照相似的原理紧密同步运行。两者都需要在每个细胞周期中进行一轮复制，并且都受关键蛋白激酶活性的控制。然而，我们对精确的细胞机制以及同步这两个周期的关键调节因子的理解仍然很有限。在这里，我们提出假设，即有丝分裂激酶活性的动态平衡的时空调节形成了一个分子钟，控制着细胞周期和中心体周期的同步进行。
