Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne, Rue du Bugnon 46, Lausanne 1011, Switzerland.
Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne, Rue du Bugnon 46, Lausanne 1011, Switzerland; Service of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Department of Medicine, Geneva University Hospitals (HUG), Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
Mult Scler Relat Disord. 2024 Oct;90:105808. doi: 10.1016/j.msard.2024.105808. Epub 2024 Aug 6.
Environmental and lifestyle factors are associated with an increased risk of Multiple Sclerosis (MS). Metabolic syndrome (MetS) contributes to systemic inflammation, which is associated with poorer MS disease evolution. We compared persons with MS (PwMS) and controls to assess metabolic and lifestyle parameters associated with MS.
We pooled data from two prospective observational studies with the same eligibility criteria, matching PwMS and controls (1:2 ratio) by sex, age, and body mass index (BMI). We compared anthropometric, biological and lifestyle parameters, including sleep and physical activity.
We included 53 PwMS and 106 controls with a median age of 35 years and 79% of women. PwMS had low Expanded Disability Status Scale (median 1.5). Compared to controls, PwMS had increased waist-to-hip (p<0.001) and waist-to-height (p=0.007) ratios, and practiced less physical activity (p=0.03). In regression models, lifestyle factors with the strongest factor loadings to predict central obesity were processed food consumption, and vigorous physical activity.
Although both groups were matched by age, sex, and BMI, we found increased central obesity in PwMS. Even with minimal neurological impairment, PwMS practiced less physical activity. This suggests that improvement of lifestyle and metabolic parameters should be targeted in MS.
环境和生活方式因素与多发性硬化症（MS）的风险增加有关。代谢综合征（MetS）会导致全身炎症，这与 MS 疾病的恶化有关。我们比较了多发性硬化症患者（PwMS）和对照组，以评估与 MS 相关的代谢和生活方式参数。
我们汇集了两项具有相同纳入标准的前瞻性观察性研究的数据，通过性别、年龄和体重指数（BMI）对 PwMS 和对照组进行 1:2 匹配。我们比较了人体测量、生物学和生活方式参数，包括睡眠和体力活动。
我们纳入了 53 名 PwMS 和 106 名对照组，中位年龄为 35 岁，79%为女性。PwMS 的扩展残疾状况量表（EDSS）评分中位数为 1.5。与对照组相比，PwMS 的腰臀比（p<0.001）和腰高比（p=0.007）更高，体力活动较少（p=0.03）。在回归模型中，与预测中心性肥胖最强相关的生活方式因素是加工食品的消费和剧烈的体力活动。
尽管两组在年龄、性别和 BMI 方面均匹配，但我们发现 PwMS 存在中心性肥胖增加。即使神经功能损伤最小，PwMS 的体力活动也较少。这表明，MS 应针对改善生活方式和代谢参数。
