4Brain, Department of Neurology, Institute for Neuroscience, Ghent University Hospital, C. Heymanslaan 10, (route 1525), Ghent 9000, Belgium.
4Brain, Department of Neurology, Institute for Neuroscience, Ghent University Hospital, C. Heymanslaan 10, (route 1525), Ghent 9000, Belgium.
Mult Scler Relat Disord. 2022 Sep;65:104016. doi: 10.1016/j.msard.2022.104016. Epub 2022 Jul 3.
To determine the association between lifestyle risk factors with 1/ the Multiple Sclerosis Severity Score (MSSS) and 2/ ongoing subclinical brain damage in non-active MS patients on high-efficacy treatment.
Cross-sectional study in persons with Multiple Sclerosis (PwMS) investigating lifestyle factors including cognitive reserve (CR), physical activity (PA), smoking status, alcohol use, dietary habits, body mass index (BMI), blood pressure (BP) and cholesterol ratio. Data were collected through validated questionnaires, clinical and laboratory examination. Serum Neurofilament light chain (sNfL) levels were used as a proxy for ongoing brain damage in a subgroup of persons with non-active MS on high-efficacy treatment. Multiple regression analysis (MRA) models explored the relationship between lifestyle factors with the MSSS score and sNfL.
351 PwMS were included (43.04 ± 11.77 years, 69.8% female). Higher CR and PA were associated with a lower MSSS; overweight or obesity and higher systolic BP with a higher MSSS. The MRA model explained 22.2% of the variance for MSSS (R².255, adjusted R².222). Higher BMI and BP were related to lower sNfL. Twenty-3% (R².279, adjusted R².230) of the variance was explained in the MRA model for sNfL.
Our study suggests an association between a 'brain healthy lifestyle' with disability progression in MS. A cognitive and physical active lifestyle alongside a normal body weight and blood pressure may help to prevent future disability in MS. Longitudinal and interventional research is necessary to gain insight in the causal pathway of these risk factors in preventing disability progression in MS.
确定生活方式危险因素与 1/多发性硬化严重程度评分（MSSS）和 2/正在接受高效治疗的非活动期多发性硬化症患者持续亚临床脑损伤之间的关系。
对多发性硬化症患者（PwMS）进行横断面研究，调查生活方式因素，包括认知储备（CR）、身体活动（PA）、吸烟状况、饮酒习惯、饮食习惯、体重指数（BMI）、血压（BP）和胆固醇比值。通过验证过的问卷、临床和实验室检查收集数据。在接受高效治疗的非活动期多发性硬化症患者亚组中，使用血清神经丝轻链（sNfL）水平作为持续脑损伤的替代指标。多元回归分析（MRA）模型探讨了生活方式因素与 MSSS 评分和 sNfL 之间的关系。
共纳入 351 名 PwMS（43.04±11.77 岁，69.8%为女性）。较高的 CR 和 PA 与 MSSS 较低相关；超重或肥胖和较高的收缩压与 MSSS 较高相关。MRA 模型解释了 MSSS 变异的 22.2%（R².255，调整后 R².222）。较高的 BMI 和 BP 与较低的 sNfL 相关。MRA 模型解释了 sNfL 变异的 23%（R².279，调整后 R².230）。
我们的研究表明，“大脑健康的生活方式”与多发性硬化症的残疾进展之间存在关联。认知和身体活跃的生活方式，加上正常的体重和血压，可能有助于预防多发性硬化症的未来残疾。需要进行纵向和干预性研究，以深入了解这些危险因素在预防多发性硬化症残疾进展中的因果途径。
