Department of Materials Process Engineering, Nagoya University, Nagoya, Japan.
Department of Psychiatry, Shiga University of Medical Science, Shiga, Japan.
Clin Neurophysiol. 2024 Oct;166:74-86. doi: 10.1016/j.clinph.2024.07.013. Epub 2024 Jul 31.
This study aimed to identify electroencephalogram correlates of dream enactment behaviors (DEBs) and elucidate their cortical dynamics in patients with isolated/idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD).
This cross-sectional study included 15 patients with iRBD. Two REM sleep periods in routine polysomnography were compared: the 60 s preceding the DEBs ("pre-representative behavior" [preR]), and the 60 s with the least submental electromyogram activity ("background" [BG]). Six EEG frequency bands and electrooculogram were analyzed; power spectra, coherence and phase-locking values in four 15-s periods were examined to assess trends. These indices were also compared between preR and BG.
Compared with BG, significantly higher delta power in the F3 channel and gamma power in the F4 and O2 channels were observed during preR. For functional connectivity, the widespread beta-band connectivity was significantly increased during preR than BG.
Before notable REM sleep behaviors, uneven distributed higher EEG spectral power in both very low and high frequencies, and increased wide-range beta band functional connectivity, were observed over 60 s, suggesting cortical correlates to subsequent DEBs.
This study may shed light on the pathological mechanisms underlies RBD through the routine vPSG analysis, leading to detection of DEBs.
本研究旨在确定梦动行为（DEB）的脑电图相关性，并阐明孤立/特发性快速眼动（REM）睡眠行为障碍（iRBD）患者的皮质动力学。
这项横断面研究纳入了 15 名 iRBD 患者。比较了常规多导睡眠图中的两个 REM 睡眠期：DEB 前的 60 秒（“代表性行为前”[preR]），以及颏下肌电图活动最少的 60 秒（“背景”[BG]）。分析了六个 EEG 频带和眼电图；检查了四个 15 秒期的功率谱、相干性和锁相值，以评估趋势。还比较了 preR 和 BG 之间的这些指标。
与 BG 相比，preR 期间 F3 通道的 delta 功率和 F4 和 O2 通道的 gamma 功率明显更高。对于功能连接，preR 时的宽频带 beta 波段连接明显高于 BG。
在明显的 REM 睡眠行为之前，在 60 秒内观察到非常低和高频率的脑电图谱功率分布不均匀增加，以及宽范围的 beta 波段功能连接增加，这表明皮质与随后的 DEB 相关。
这项研究通过常规 vPSG 分析可能揭示 RBD 背后的病理机制，从而检测到 DEB。
