乌药烷型内酯A-D，从狭叶山胡椒根中分离得到的四种新丁内酯及其细胞毒性活性。

Linderangolides A-D, four new butanolides from the roots of Lindera angustifolia and their cytotoxic activity.

作者信息

Wei Jieqin, Guo Jiaqi, Shi Qi, Wang Yiwen, Zhou Manjia, Ren Hangjie, Ma Runchao, Ying Jiani, Meng Xiongyu, Qin Lupin, Li Huaqiang

机构信息

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Baichuan Street 260, Hangzhou 311403, China.

The Medical Research Center, Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Binwen Road 548, Hangzhou 310053, China.

出版信息

Fitoterapia. 2024 Oct;178:106180. doi: 10.1016/j.fitote.2024.106180. Epub 2024 Aug 14.

DOI:10.1016/j.fitote.2024.106180

PMID:39128554

Abstract

Four undescribed butanolides, linderangolides A-D (1-4), along with four known congeners, lincomolide A (5), (-)-epilitsenolide C2 (6), (-)-epilitsenolide C1 (7) and litseakolide H (8), were isolated from the roots of Lindera angustifolia. The planar structures of 1-4 were elucidated based on extensive spectroscopic analyses, the relative and absolute configurations of 1-4 were determined by the NOESY spectra and the comparison of calculated and experimental ECD. The cytotoxic activities of all isolated compounds were tested, 4 showed inhibitory activity against SGC-7 cells with IC value of 6.62 μM.

摘要

从狭叶山胡椒的根中分离出了四种未描述的丁内酯，即乌药内酯A-D（1-4），以及四种已知的同系物，林可莫利德A（5）、（-）-表柳叶木兰内酯C2（6）、（-）-表柳叶木兰内酯C1（7）和乌药内酯H（8）。基于广泛的光谱分析阐明了1-4的平面结构，通过NOESY光谱以及计算和实验ECD的比较确定了1-4的相对和绝对构型。测试了所有分离化合物的细胞毒性活性，化合物4对SGC-7细胞显示出抑制活性，IC值为6.62 μM。