Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an 710069, China.
Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China.
J Agric Food Chem. 2024 Aug 21;72(33):18537-18551. doi: 10.1021/acs.jafc.4c04949. Epub 2024 Aug 11.
Diabetes mellitus is a typical metabolic disease that has become a major threat to human health worldwide. Ginseng polypeptide (GP), a small molecule active substance isolated from ginseng, has shown positive hypoglycemic effects in preliminary studies. However, its mechanism in ameliorating multiorgan damage in db/db mice is unclear. In this study, we utilized network pharmacology, molecular docking, and animal experiments to explore the targets and biological mechanisms of GP to ameliorate multiorgan damage in T2DM. The results showed that GP improves T2DM by inhibiting inflammation and oxidative damage, thereby alleviating hyperglycemia, insulin resistance, and multiorgan damage in db/db mice. These effects are potentially mediated through the PI3K-Akt signaling pathway and the MAPK signaling pathway. This study establishes GP's efficacy in alleviating T2DM and provides a robust theoretical basis for the development of new drugs or functional foods for treating this disease.
糖尿病是一种典型的代谢性疾病，已成为全球范围内人类健康的主要威胁。人参多肽（GP）是从人参中分离得到的一种小分子活性物质，初步研究显示其具有降血糖作用。然而，其改善 db/db 小鼠多器官损伤的机制尚不清楚。本研究采用网络药理学、分子对接和动物实验等方法，探讨 GP 改善 T2DM 多器官损伤的作用靶点和生物学机制。结果表明，GP 通过抑制炎症和氧化损伤改善 T2DM，从而减轻 db/db 小鼠的高血糖、胰岛素抵抗和多器官损伤。这些作用可能是通过 PI3K-Akt 信号通路和 MAPK 信号通路介导的。本研究确立了 GP 缓解 T2DM 的功效，为开发治疗该疾病的新药或功能性食品提供了有力的理论依据。
