Department of Family Medicine, Erenkoy Psychiatry and Neurology Training and Research Hospital, 34736 Istanbul, Türkiye.
Department of Psychiatry, Bakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, 34147 Istanbul, Türkiye.
Actas Esp Psiquiatr. 2024 Aug;52(4):503-511. doi: 10.62641/aep.v52i4.1629.
Recent research has demonstrated that the dorsal striatum is directly associated with the integration of cognitive, sensory-motor, and motivational/emotional data. Disruptions in the corticostriatal circuit have been implicated in the pathophysiology of psychosis. The dorsal striatum was reported to show lateralized pathology in psychotic disorders. In this study, we aimed to analyze the laterality of the dorsal striatum with texture analysis of T2-weighted magnetic resonance imaging (MRI) images from schizoaffective disorder (SAD) patients.
Twenty SAD patients, met the inclusion criteria and had available cranial MRI data were assigned as the patient group. Twenty healthy individuals were determined as the control group. Texture analysis values were obtained from striatum region of interests (ROI) generated from T2-weighted MRI images. Data are presented as mean and standard deviation. The suitability of the data for normal distribution was analyzed with the Kolmogorov-Smirnov test. Analysis of variance (ANOVA) test (Post Hoc TUKEY) was employed to compare the group data based on test findings.
There was no significant difference between the groups in terms of gender and age. There were differences in the values of texture analysis parameters of both caudate and putamen nuclei in comparison to controls. We identified differences in the left dorsal striatum nuclei in SAD. The differences in the putamen were more and more pronounced than in the caudate.
Texture analyses suggest that the left dorsal striatum nuclei may be different in SAD patients. Further studies are needed to determine the pathophysiology of SAD and how it may affect disease treatment.
最近的研究表明，背侧纹状体直接与认知、感觉运动和动机/情感数据的整合有关。皮质纹状体回路的中断与精神病的病理生理学有关。据报道，背侧纹状体在精神病障碍中表现出偏侧化的病理。在这项研究中，我们旨在通过对精神分裂情感障碍（SAD）患者的 T2 加权磁共振成像（MRI）图像进行纹理分析来分析背侧纹状体的偏侧性。
20 名符合纳入标准且有头颅 MRI 数据的 SAD 患者被分配为患者组。20 名健康个体被确定为对照组。从 T2 加权 MRI 图像生成纹状体感兴趣区（ROI），从中获取纹理分析值。数据以平均值和标准差表示。使用 Kolmogorov-Smirnov 检验分析数据是否适合正态分布。根据检验结果，采用方差分析（ANOVA）检验（事后 TUKEY）比较组间数据。
两组在性别和年龄方面无显著差异。与对照组相比，尾状核和壳核的纹理分析参数值存在差异。我们发现 SAD 患者左背侧纹状体核存在差异。壳核的差异比尾状核更明显。
纹理分析表明，SAD 患者的左背侧纹状体核可能不同。需要进一步研究来确定 SAD 的病理生理学以及它如何影响疾病治疗。
