Cai Chenxi, Yuan Kai, Yin Junsen, Feng Dan, Bi Yanzhi, Li Yangding, Yu Dahua, Jin Chenwang, Qin Wei, Tian Jie
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, People's Republic of China.
Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
Brain Imaging Behav. 2016 Mar;10(1):12-20. doi: 10.1007/s11682-015-9358-8.
Internet gaming disorder (IGD), identified in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) Section III as a condition warranting more clinical research, may be associated with impaired cognitive control. Previous IGD-related studies had revealed structural abnormalities in the prefrontal cortex, an important part of prefrontal-striatal circuits, which play critical roles in cognitive control. However, little is known about the relationship between the striatal nuclei (caudate, putamen, and nucleus accumbens) volumes and cognitive control deficit in individuals with IGD. Twenty-seven adolescents with IGD and 30 age-, gender- and education-matched healthy controls participated in this study. The volume differences of the striatum were assessed by measuring subcortical volume in FreeSurfer. Meanwhile, the Stroop task was used to detect cognitive control deficits. Correlation analysis was used to investigate the relationship between striatal volumes and performance in the Stroop task as well as severity in IGD. Relative to controls, the IGD committed more incongruent condition response errors during the Stroop task and showed increased volumes of dorsal striatum (caudate) and ventral striatum (nucleus accumbens). In addition, caudate volume was correlated with Stroop task performance and nucleus accumbens (NAc) volume was associated with the internet addiction test (IAT) score in the IGD group. The increased volumes of the right caudate and NAc and their association with behavioral characteristics (i.e., cognitive control and severity) in IGD were detected in the present study. Our findings suggest that the striatum may be implicated in the underlying pathophysiology of IGD.
互联网游戏障碍（IGD）在《精神疾病诊断与统计手册》（DSM - V）第三版中被确定为一种需要更多临床研究的病症，可能与认知控制受损有关。先前与IGD相关的研究已经揭示了前额叶皮质的结构异常，前额叶 - 纹状体回路的一个重要部分，其在认知控制中起关键作用。然而，对于患有IGD的个体，纹状体核（尾状核、壳核和伏隔核）体积与认知控制缺陷之间的关系知之甚少。27名患有IGD的青少年和30名年龄、性别和教育程度匹配的健康对照参与了本研究。通过在FreeSurfer中测量皮质下体积来评估纹状体的体积差异。同时，使用Stroop任务来检测认知控制缺陷。相关性分析用于研究纹状体体积与Stroop任务表现以及IGD严重程度之间的关系。相对于对照组，患有IGD的个体在Stroop任务中出现了更多不一致条件反应错误，并且显示背侧纹状体（尾状核）和腹侧纹状体（伏隔核）体积增加。此外，在IGD组中，尾状核体积与Stroop任务表现相关，伏隔核（NAc）体积与互联网成瘾测试（IAT）得分相关。本研究检测到右侧尾状核和NAc体积增加及其与IGD行为特征（即认知控制和严重程度）的关联。我们的研究结果表明，纹状体可能与IGD的潜在病理生理学有关。
