Bliumkin V N, Ivanov A E
Biull Eksp Biol Med. 1979 Sep;88(9):355-8.
The structure of allotransplanted kidneys (AK) from human cadavers that remained in the recipient's body for a long time (4 months-6 years) has been studied. AK that preserved good function up to the patient's death not consequent on the transplant insufficiency showed a weak immunocellular connective tissue, with the epithelium of proximal canaliculi being cytologically reconstructed. The reconstruction lay in formation of numerous polykaryocytes having a hypertrophied brush-like outline. This phenomenon ("proximal polykaryocytosis") is assessed as a manifestation of regeneratory potencies of the epithelium of AK proximal tubules in late periods after transplantation. Chronic moderate hypoxia of AK was conducive to reconstruction of the epithelium of the nephron proximal part. Inadequate function of AK was related to the development of chronic rejection resistant to the treatment, and AK demonstrated an intensive immunocellular reaction and developed gross sclerosis that produced atrophy of most AK tubular.
对在受体体内留存较长时间（4个月至6年）的人类尸体同种异体移植肾（AK）的结构进行了研究。在移植功能不全并非导致患者死亡原因的情况下，直至患者死亡仍保持良好功能的AK显示出免疫细胞结缔组织较弱，近端小管上皮在细胞学上得以重建。重建表现为形成众多具有肥大刷状轮廓的多核细胞。这种现象（“近端多核细胞增多症”）被评估为移植后期AK近端小管上皮再生潜能的一种表现。AK的慢性中度缺氧有利于肾单位近端部分上皮的重建。AK功能不足与对治疗有抗性的慢性排斥反应的发展有关，并且AK表现出强烈的免疫细胞反应并出现严重硬化，导致大多数AK小管萎缩。
