Lai Shih-Wei, Kuo Yu-Hung, Liao Kuan-Fu
Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
Open Forum Infect Dis. 2024 Jul 11;11(8):ofae394. doi: 10.1093/ofid/ofae394. eCollection 2024 Aug.
Coronary artery disease (CAD) and herpes zoster represent significant health burdens, and their potential interrelationships remain understudied. This cohort study aimed to address the existing knowledge gap by systematically exploring whether people with CAD are at increased risk for developing herpes zoster.
Using the 2006-2015 claims data of the National Health Insurance Program in Taiwan, we identified participants aged ≥20 years with a new diagnosis of CAD as the CAD group. We selected sex- and age-matched participants without CAD as the non-CAD group. The incidence rate of herpes zoster at the end of follow-up was calculated. A multivariable Cox proportional hazards regression model was used to measure the hazard ratio and 95% CI for herpes zoster associated with covariables.
The overall incidence rate of herpes zoster was 1.14-fold greater in the CAD group as compared with the non-CAD group (6.52 vs 5.74 per 1000 person-years; 95% CI, 1.08-1.20). After controlling for covariables, the adjusted hazard ratio of herpes zoster was 1.21 (95% CI, 1.14-1.27) for the CAD group as compared with the non-CAD group.
This cohort study provides valuable insights into the potential association between CAD and the risk of developing herpes zoster. The findings may have implications for preventive strategies of herpes zoster in people with CAD. Further research and collaboration with diverse groups will be critical to validate and extend our findings.
冠状动脉疾病（CAD）和带状疱疹是重大的健康负担，它们之间潜在的相互关系仍未得到充分研究。这项队列研究旨在通过系统探索CAD患者发生带状疱疹的风险是否增加来填补现有知识空白。
利用台湾国民健康保险计划2006 - 2015年的理赔数据，我们将年龄≥20岁且新诊断为CAD的参与者确定为CAD组。我们选择年龄和性别匹配的无CAD参与者作为非CAD组。计算随访结束时带状疱疹的发病率。采用多变量Cox比例风险回归模型来衡量与协变量相关的带状疱疹的风险比和95%置信区间。
CAD组带状疱疹的总体发病率比非CAD组高1.14倍（每1000人年分别为6.52例和5.74例；95%置信区间，1.08 - 1.20）。在控制协变量后，与非CAD组相比，CAD组带状疱疹的调整后风险比为1.21（95%置信区间，1.14 - 1.27）。
这项队列研究为CAD与发生带状疱疹风险之间的潜在关联提供了有价值的见解。这些发现可能对CAD患者带状疱疹的预防策略有启示。进一步的研究以及与不同群体的合作对于验证和扩展我们的发现至关重要。
