Lai Shih-Wei, Lin Cheng-Li, Liao Kuan-Fu
College of Medicine, China Medical University.
Department of Family Medicine.
Medicine (Baltimore). 2019 May;98(18):e15463. doi: 10.1097/MD.0000000000015463.
Little evidence is available about the correlation between diabetes mellitus and herpes zoster in Taiwan. This study aimed to investigate the correlation between diabetes mellitus and herpes zoster in Taiwan.A population-based cohort study was conducted using the database of Taiwan National Health Insurance Program. There were 27,369 subjects aged 20 to 84 years with newly diagnosed diabetes mellitus from 2000 to 2012 as the diabetes mellitus group and 107,705 sex- and age-matched subjects without diabetes mellitus as the nondiabetes mellitus group. The incidence of herpes zoster at the end of 2013 was estimated. The multivariable Cox proportional hazards regression model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) of herpes zoster associated with diabetes mellitus.The overall incidence of herpes zoster was 1.16-fold higher in the diabetes mellitus group than the nondiabetes mellitus group (7.85 vs 6.75 per 1000 person-years, 95% CI 1.12-1.20). After adjustment for co-variables, the adjusted HR of herpes zoster was 1.17 for subjects with diabetes mellitus (95% CI 1.10-1.23), compared with subjects without diabetes mellitus.Patients with diabetes mellitus are associated with 1.17-fold increased risk for developing herpes zoster.
在台湾，关于糖尿病与带状疱疹之间相关性的证据很少。本研究旨在调查台湾地区糖尿病与带状疱疹之间的相关性。
采用台湾全民健康保险计划数据库进行了一项基于人群的队列研究。将2000年至2012年新诊断为糖尿病的27369名20至84岁受试者作为糖尿病组，将107705名性别和年龄匹配的非糖尿病受试者作为非糖尿病组。估算了2013年底带状疱疹的发病率。使用多变量Cox比例风险回归模型计算与糖尿病相关的带状疱疹的风险比（HR）和95%置信区间（CI）。
糖尿病组带状疱疹的总体发病率比非糖尿病组高1.16倍（每1000人年分别为7.85例和6.75例，95%CI 1.12 - 1.20）。在对协变量进行调整后，糖尿病患者带状疱疹的调整后HR为1.17（95%CI 1.10 - 1.23），与非糖尿病患者相比。糖尿病患者发生带状疱疹的风险增加1.17倍。
