Mahajan Gundappa, Elangbam Priya, Babu Manu S, Suresh Anvita
Department of ENT, Dr D Y Patil Medical College and Hospital, Pimpri, Pune, Maharashtra India.
Panjim, India.
Indian J Otolaryngol Head Neck Surg. 2024 Aug;76(4):3485-3489. doi: 10.1007/s12070-024-04576-0. Epub 2024 Mar 20.
A nodular lesion of the tongue encompasses a range of conditions, from reactive to malignant. It can be challenging to diagnose when a solitary and firm submucosal mass appears in the oral cavity. Following an essential investigation protocol is necessary for reaching a definitive diagnosis. Leiomyomas are benign tumors that infrequently occur in the oral cavity and typically affect individuals between their forties and fifties. This case report presents a rare and unique case of a giant submucosal fibromatosis located at the base of the tongue in a 3-year-old child presenting with features of pediatric OSA. Immunohistochemical analysis revealed the positivity of tumor cells for beta-catenin and CD 34 aberrant expression, though SMA and STAT 6 were negative. The lesion was removed submucosally in toto and post-surgery the patient showed no symptoms and had no evidence of tumors during the one-year follow-up visit.
舌部结节性病变涵盖了从反应性到恶性的一系列病症。当口腔中出现孤立且质地坚硬的黏膜下肿物时,诊断可能具有挑战性。遵循基本的检查方案对于做出明确诊断是必要的。平滑肌瘤是罕见发生于口腔的良性肿瘤,通常影响四五十岁的个体。本病例报告呈现了一例罕见且独特的巨大黏膜下纤维瘤病,位于一名3岁儿童的舌根处,该患儿具有小儿阻塞性睡眠呼吸暂停(OSA)的特征。免疫组化分析显示肿瘤细胞β-连环蛋白呈阳性,CD 34表达异常,而平滑肌肌动蛋白(SMA)和信号转导和转录激活因子6(STAT 6)呈阴性。病变通过黏膜下完整切除,术后患者无症状,在一年的随访期间未发现肿瘤迹象。