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The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives.2020 年世界卫生组织软组织肿瘤分类:新闻与展望。
Pathologica. 2021 Apr;113(2):70-84. doi: 10.32074/1591-951X-213. Epub 2020 Nov 3.
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Revaluing the role of the tongue in obstructive sleep apnea.重新评估舌头在阻塞性睡眠呼吸暂停中的作用。
J Bras Pneumol. 2019 Sep 5;45(4):e20190208. doi: 10.1590/1806-3713/e20190208.
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Optimal radiotherapy strategy for primary or recurrent fibromatosis and long-term results.原发性或复发性纤维瘤病的最佳放疗策略及长期疗效。
PLoS One. 2018 May 29;13(5):e0198134. doi: 10.1371/journal.pone.0198134. eCollection 2018.
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Misdiagnosis of aggressive fibromatosis of the abdominal wall: A case report and literature review.腹壁侵袭性纤维瘤病的误诊:一例报告及文献复习
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Aggressive fibromatosis of the oral cavity in a 5 year old boy: a rare case report.一名5岁男孩口腔侵袭性纤维瘤病:罕见病例报告
Pan Afr Med J. 2017 May 18;27:47. doi: 10.11604/pamj.2017.27.47.11739. eCollection 2017.
8
EXTRA-ABDOMINAL DESMOID TUMOR: LOCAL RECURRENCE AND TREATMENT OPTIONS.腹外硬纤维瘤:局部复发与治疗选择
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9
Consequences of Obstructive Sleep Apnea in Children.儿童阻塞性睡眠呼吸暂停的后果
Curr Probl Pediatr Adolesc Health Care. 2016 Jan;46(1):19-26. doi: 10.1016/j.cppeds.2015.10.007. Epub 2015 Nov 26.
10
Corticosteroids and immune checkpoint blockade.皮质类固醇与免疫检查点阻断
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表现为小儿阻塞性睡眠呼吸暂停的巨大舌根部黏膜下纤维瘤病:1例罕见病例报告

Giant Submucosal Fibromatosis of the Base of Tongue Presenting as Paediatric Obstuctive Sleep Apnoea: A Rare Case Report.

作者信息

Mahajan Gundappa, Elangbam Priya, Babu Manu S, Suresh Anvita

机构信息

Department of ENT, Dr D Y Patil Medical College and Hospital, Pimpri, Pune, Maharashtra India.

Panjim, India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2024 Aug;76(4):3485-3489. doi: 10.1007/s12070-024-04576-0. Epub 2024 Mar 20.

DOI:10.1007/s12070-024-04576-0
PMID:39130245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11306888/
Abstract

A nodular lesion of the tongue encompasses a range of conditions, from reactive to malignant. It can be challenging to diagnose when a solitary and firm submucosal mass appears in the oral cavity. Following an essential investigation protocol is necessary for reaching a definitive diagnosis. Leiomyomas are benign tumors that infrequently occur in the oral cavity and typically affect individuals between their forties and fifties. This case report presents a rare and unique case of a giant submucosal fibromatosis located at the base of the tongue in a 3-year-old child presenting with features of pediatric OSA. Immunohistochemical analysis revealed the positivity of tumor cells for beta-catenin and CD 34 aberrant expression, though SMA and STAT 6 were negative. The lesion was removed submucosally in toto and post-surgery the patient showed no symptoms and had no evidence of tumors during the one-year follow-up visit.

摘要

舌部结节性病变涵盖了从反应性到恶性的一系列病症。当口腔中出现孤立且质地坚硬的黏膜下肿物时,诊断可能具有挑战性。遵循基本的检查方案对于做出明确诊断是必要的。平滑肌瘤是罕见发生于口腔的良性肿瘤,通常影响四五十岁的个体。本病例报告呈现了一例罕见且独特的巨大黏膜下纤维瘤病,位于一名3岁儿童的舌根处,该患儿具有小儿阻塞性睡眠呼吸暂停(OSA)的特征。免疫组化分析显示肿瘤细胞β-连环蛋白呈阳性,CD 34表达异常,而平滑肌肌动蛋白(SMA)和信号转导和转录激活因子6(STAT 6)呈阴性。病变通过黏膜下完整切除,术后患者无症状,在一年的随访期间未发现肿瘤迹象。