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功能性内窥镜鼻窦手术后麦卢卡蜂蜜与婴儿洗发水鼻腔冲洗程序的比较:一项前瞻性对照研究

Comparison between Manuka Honey and Baby Shampoo Nasal Douching Procedures After Functional Endoscopic Sinus Surgery: a Prospective Comparative.

作者信息

Thejas Saai Ram, Sadhana Yalla Sri, Mohammed Rishiraj, Harika Rao Aditya Jnana

机构信息

Department of Otorhinolaryngology and Head & NeckSurgery, RVM Institute of Medical Sciences, Telangana, India.

RVM Institute of Medical Sciences, Telangana, India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2024 Aug;76(4):3075-3080. doi: 10.1007/s12070-024-04605-y. Epub 2024 Mar 14.

DOI:10.1007/s12070-024-04605-y
PMID:39130340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11306809/
Abstract

INTRODUCTION

Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of nasal and paranasal sinus mucosa where symptomatology has continued beyond 12 weeks. Manuka honey is made by bees that pollinate the native leptospermum scoparium bush (tea tree). Baby shampoo is a commercially available liquid solution containing multiple chemical surfactants that can act as a mucolytic and an antimicrobial agent.

MATERIALS AND METHODS

Fifty patients diagnosed with CRS were taken to be part of study. The modes of comparison used were the Rhinosinusitis Disability Index (RSDI) and a self-formulated Nasal Crusting Score (NCS). Individuals in Group A were given 5% Manuka Honey for nasal douching in both nasal cavities and those in Group B were given 10% Baby Shampoo.

OBSERVATIONS AND RESULTS

The average RSDI scores in Group A before & after intervention were 75.40 and 30.04, an improvement of 60.15%. The same parameters in Group B was found to be 77.36 and 37.36, an improvement of 51.70%. The NCS improved by 83.46% in the Group A and by 77.61% in Group B between POD-2 and POD-5.

CONCLUSION

As per literature available, both Manuka Honey and Baby Shampoo have improved the outcomes of Quality of Life and airway after FESS. We found that Manuka Honey is superior in clearing crusts and achieving better symptom clearance post FESS. We also present our self-formulated Nasal Crusting Score which can be used in further practice for better understanding of nasal airway.

摘要

引言

慢性鼻-鼻窦炎(CRS)是一种鼻腔和鼻窦黏膜的慢性炎症性疾病,其症状持续超过12周。麦卢卡蜂蜜由蜜蜂采集本地茶树(互叶白千层)花丛中的花蜜酿造而成。婴儿洗发水是一种市售的液体溶液,含有多种化学表面活性剂,可作为黏液溶解剂和抗菌剂。

材料与方法

选取50例被诊断为CRS的患者作为研究对象。采用的比较方式为鼻-鼻窦炎残疾指数(RSDI)和自行制定的鼻痂评分(NCS)。A组患者双侧鼻腔均使用5%的麦卢卡蜂蜜进行鼻腔冲洗,B组患者则使用10%的婴儿洗发水。

观察与结果

A组干预前后的平均RSDI评分分别为75.40和30.04,改善率为60.15%。B组的相同参数分别为77.36和37.36,改善率为51.70%。在术后第2天(POD-2)至术后第5天(POD-5)期间,A组的NCS改善了83.46%,B组改善了77.61%。

结论

根据现有文献,麦卢卡蜂蜜和婴儿洗发水在功能性内镜鼻窦手术(FESS)后均改善了生活质量和气道状况。我们发现,麦卢卡蜂蜜在清除痂皮和FESS术后实现更好的症状清除方面更具优势。我们还展示了自行制定的鼻痂评分,可在进一步的实践中用于更好地了解鼻气道情况。

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本文引用的文献

1
Sinonasal Irrigation After Endoscopic Sinus surgery - Past to Present and Future.鼻内镜手术后的鼻腔冲洗——从过去到现在及未来
Indian J Otolaryngol Head Neck Surg. 2023 Apr 29;75(3):1-8. doi: 10.1007/s12070-023-03525-7.
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Comparison of effects of baby shampoo vs. saline irrigation on endoscopic sinus surgery outcomes and quality of life.婴儿洗发水与生理盐水冲洗对鼻内镜鼻窦手术效果及生活质量的影响比较。
Auris Nasus Larynx. 2021 Jun;48(3):408-414. doi: 10.1016/j.anl.2020.08.009. Epub 2020 Aug 26.
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Manuka honey sinus irrigation for the treatment of chronic rhinosinusitis: a randomized controlled trial.麦卢卡蜂蜜鼻窦冲洗治疗慢性鼻-鼻窦炎:一项随机对照试验。
Int Forum Allergy Rhinol. 2017 Apr;7(4):365-372. doi: 10.1002/alr.21898. Epub 2016 Dec 9.
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Chronic sinusitis pathophysiology: the role of allergy.慢性鼻窦炎的病理生理学:过敏的作用。
Am J Rhinol Allergy. 2013 Sep-Oct;27(5):367-71. doi: 10.2500/ajra.2013.27.3906. Epub 2013 Apr 18.
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Topical therapies in the management of chronic rhinosinusitis: an evidence-based review with recommendations.慢性鼻-鼻窦炎局部治疗:基于证据的综述及推荐。
Int Forum Allergy Rhinol. 2013 Apr;3(4):281-98. doi: 10.1002/alr.21096. Epub 2012 Oct 8.
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Methylglyoxal-infused honey mimics the anti-Staphylococcus aureus biofilm activity of manuka honey: potential implication in chronic rhinosinusitis.甲基乙二醛浸渍蜂蜜模拟麦卢卡蜂蜜抗金黄色葡萄球菌生物膜活性:在慢性鼻-鼻窦炎中的潜在意义。
Laryngoscope. 2011 May;121(5):1104-7. doi: 10.1002/lary.21717.
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Do biofilms contribute to the initiation and recalcitrance of chronic rhinosinusitis?生物膜是否有助于慢性鼻-鼻窦炎的发生和难治性?
Laryngoscope. 2011 May;121(5):1085-91. doi: 10.1002/lary.21438.
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Baby shampoo nasal irrigations for the symptomatic post-functional endoscopic sinus surgery patient.针对功能性鼻内镜鼻窦手术后有症状的患者,使用婴儿洗发水进行鼻腔冲洗。
Am J Rhinol. 2008 Jan-Feb;22(1):34-7. doi: 10.2500/ajr.2008.22.3122.
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Shampoos: ingredients, efficacy and adverse effects.洗发水:成分、功效及不良反应
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