Du Quansheng, Li Juan, Yang Fang, Dai Hui, Wu Aiguo
National Natural Science Foundation of China, Beijing 100085, China.
Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
Research (Wash D C). 2024 Aug 9;7:0430. doi: 10.34133/research.0430. eCollection 2024.
"Boundarics in Biomedicine" is a cutting-edge interdisciplinary discipline, which is of great significance for understanding the origin of life, the interaction between internal and external environments, and the mechanism of disease occurrence and evolution. Here, the definition of Boundarics in Biomedicine is first described, including its connotation, research object, research method, challenges, and future perspectives. "Boundarics in Biomedicine" is a cutting-edge interdisciplinary discipline involving multiple fields (e.g., bioscience, medicine, chemistry, materials science, and information science) dedicated to investigating and solving key scientific questions in the formation, identification, and evolution of living organism boundaries. Specifically, it encompasses 3 levels: (a) the boundary between the living organism and the external environment, (b) internal boundary within living organism, and (c) the boundary related to disease in living organism. The advancement of research in Boundarics in Biomedicine is of great scientific significance for understanding the origin of life, the interaction between internal and external environments, and the mechanism of disease occurrence and evolution, thus providing novel principles, technologies, and methods for early diagnosis and prevention of major diseases, personalized drug development, and prognosis assessment (Fig. 1).
“生物医学中的边界”是一门前沿交叉学科，对于理解生命起源、内外环境相互作用以及疾病发生和演变机制具有重要意义。在此，首先描述“生物医学中的边界”的定义，包括其内涵、研究对象、研究方法、挑战和未来展望。“生物医学中的边界”是一门前沿交叉学科，涉及多个领域（如生物科学、医学、化学、材料科学和信息科学），致力于研究和解决生物体边界形成、识别和演变中的关键科学问题。具体而言，它涵盖三个层面：（a）生物体与外部环境之间的边界，（b）生物体内的内部边界，以及（c）生物体内与疾病相关的边界。“生物医学中的边界”研究的进展对于理解生命起源、内外环境相互作用以及疾病发生和演变机制具有重大科学意义，从而为重大疾病的早期诊断和预防、个性化药物开发以及预后评估提供新的原理、技术和方法（图1）。
