Kortenbrede Lana, Heider Johanna, Heckroth Heike, Leimenstoll Marc, Steuer Heiko, Sütterlin Jan, Weise Frank, Hokamp Tobias
Covestro Deutschland AG, Coatings and Adhesives, Leverkusen 51365, Germany.
NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen 72770, Germany.
ACS Omega. 2024 Jul 25;9(31):34008-34020. doi: 10.1021/acsomega.4c04577. eCollection 2024 Aug 6.
Postoperative peritoneal adhesions occur after more than 60% of abdominal surgeries and can cause severe long-term side effects, such as chronic pain, infertility, and intestinal obstructions. However, currently available products for adhesion prophylaxis often lack efficiency or are too heavy to handle. Hydrogels are promising materials to be used for adhesion prevention as they show good mechanical stability and biocompatibility. Herein, we present a novel two-component sprayable, biodegradable, fast-curing, and shape-adaptive polyurethane urea (PUU) hydrogel system and the establishment of a full characterization approach to investigate its suitability for adhesion prophylaxis according to predefined chemical, mechanical, and biological criteria. We demonstrate that this PUU hydrogel system exhibits a fast-curing behavior, is resilient toward mechanical forces, is biocompatible, and reveals a degradation behavior within a desired time frame to reliably avoid the formation of adhesions. In addition, the PUU hydrogel system functions as an effective barrier for invading cells . Overall, we propose a guideline for the development and characterization of synthetic hydrogels for application in minimally invasive adhesion prophylaxis.
超过60%的腹部手术后会发生术后腹膜粘连，并且可能导致严重的长期副作用，如慢性疼痛、不孕和肠梗阻。然而，目前可用的预防粘连的产品往往缺乏有效性，或者操作起来过于笨重。水凝胶是有前景的用于预防粘连的材料，因为它们具有良好的机械稳定性和生物相容性。在此，我们展示了一种新型的双组分可喷涂、可生物降解、快速固化且形状自适应的聚氨酯脲（PUU）水凝胶系统，并建立了一种全面的表征方法，以根据预定义的化学、机械和生物学标准研究其用于预防粘连的适用性。我们证明，这种PUU水凝胶系统表现出快速固化行为，对机械力具有弹性，具有生物相容性，并且在期望的时间范围内呈现降解行为，以可靠地避免粘连的形成。此外，PUU水凝胶系统对侵入细胞起到有效的屏障作用。总体而言，我们提出了用于开发和表征用于微创粘连预防的合成水凝胶的指导原则。
