Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, Wuhan 430071, China.
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, Wuhan 430071, China.
Carbohydr Polym. 2023 Apr 1;305:120543. doi: 10.1016/j.carbpol.2023.120543. Epub 2023 Jan 5.
Postoperative peritoneal adhesions are common complications caused by abdominal and pelvic surgery, which seriously impact the quality of life of patients and impose additional financial burdens. Using of biomedical materials as physical barriers to completely isolate the traumatic organ and injured tissue is an optimal strategy for preventing postoperative adhesions. However, the limited efficacy and difficulties in the complete degradation or integration of biomedical materials with living tissues restrict the application of these materials. In this study, novel chitin-based crosslinked hydrogels with appropriate mechanical properties and flexibilities were developed using a facile and green strategy. The developed hydrogels simultaneously exhibited excellent biocompatibilities and resistance to nonspecific protein adsorption and NIH/3T3 fibroblast adhesion. Furthermore, these hydrogels were biodegradable and could be completely integrated into the native extracellular matrix. The chitin-based crosslinked hydrogels also effectively inhibited postoperative peritoneal adhesions in rat models of adhesion and recurrence. Therefore, these novel chitin-based crosslinked hydrogels are excellent candidate physical barriers for the efficient prevention of postoperative peritoneal adhesions and provide a new anti-adhesion strategy for biomedical applications.
术后腹膜粘连是腹部和骨盆手术常见的并发症，严重影响患者的生活质量，并带来额外的经济负担。使用生物医学材料作为物理屏障，将创伤性器官和受损组织完全隔离，是预防术后粘连的最佳策略。然而，生物医学材料的有限功效以及与活组织完全降解或整合的困难，限制了这些材料的应用。在这项研究中，我们采用一种简单而绿色的策略，开发出了具有适当机械性能和柔韧性的新型甲壳素交联水凝胶。所开发的水凝胶同时表现出优异的生物相容性以及对非特异性蛋白吸附和 NIH/3T3 成纤维细胞黏附的抵抗力。此外，这些水凝胶可生物降解，并可完全整合到天然细胞外基质中。基于甲壳素的交联水凝胶还能有效抑制粘连和复发大鼠模型中的术后腹膜粘连。因此，这些新型甲壳素交联水凝胶是高效预防术后腹膜粘连的理想物理屏障，为生物医学应用提供了一种新的抗粘连策略。
