不同饮食条件下小鼠血浆的比较代谢组学分析。
Comparative metabolomic analysis of mouse plasma in response to different dietary conditions.
作者信息
Yang So Hwi, Kim Ye Jin, Lee HanGyeol, Seo Woo Duck, Kwon Eun Young, Kim Jae Kwang
机构信息
Division of Life Sciences, College of Life Sciences, and Bioengineering, Incheon National University, Inchon, 22012 Republic of Korea.
Division of Crop Foundation, National Institute of Crop Science, Rural Development Administration, Wanju, Jeonbuk 55365 Republic of Korea.
出版信息
Food Sci Biotechnol. 2023 Dec 1;33(9):2169-2178. doi: 10.1007/s10068-023-01479-8. eCollection 2024 Jul.
UNLABELLED
Plasma metabolites offer insights into aging processes and aging-related biomarkers. Here, the dietary effects of various functional foods on older adult mice were evaluated using metabolomic techniques. Fifty-week-old mice were divided into four groups (n = 4 each) and fed either a normal diet (AC) or the diets from sprout (TA), (SZ), or sprout (PS) extracts. Additionally, a group of 8-week-old mice fed a normal diet (YC; n = 5) was included for the comparison. The PS group had a significantly lower free fatty acid content and higher ornithine, proline, citric acid, and oxalic acid contents than the AC group. The PS group also showed reduced oxidative stress and muscle damage, suggesting the higher anti-aging efficacy of sprouts than the other diets. These findings suggest plasma metabolite profiling is an effective tool to assess the anti-aging effects of functional foods.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s10068-023-01479-8.
未标注
血浆代谢物有助于深入了解衰老过程和与衰老相关的生物标志物。在此，使用代谢组学技术评估了各种功能性食品对老年小鼠的饮食影响。将50周龄的小鼠分为四组（每组n = 4），分别喂食正常饮食（AC）或来自豆芽（TA）、（SZ）或苜蓿芽（PS）提取物的饮食。此外，还纳入了一组喂食正常饮食的8周龄小鼠（YC；n = 5）用于比较。与AC组相比，PS组的游离脂肪酸含量显著降低，鸟氨酸、脯氨酸、柠檬酸和草酸含量更高。PS组还显示出氧化应激和肌肉损伤减少，表明苜蓿芽的抗衰老功效高于其他饮食。这些发现表明血浆代谢物谱分析是评估功能性食品抗衰老作用的有效工具。
补充信息
在线版本包含可在10.1007/s10068-023-01479-8获取的补充材料。
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