Karmore Sakshi, Mude Gaurav S
Clinical Research, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Pharmacology, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2024 Jul 10;16(7):e64260. doi: 10.7759/cureus.64260. eCollection 2024 Jul.
Idiopathic thrombocytopenic purpura (ITP) is characterized by a persistently low platelet count, which can lead to serious bleeding such as gastritis and hemorrhagic stroke. The formation of auto-antibodies in ITP leads to increased destruction of platelets and then hampers hematopoiesis. Corticosteroids and intravenous immunoglobulin are among the common treatments used for ITP, but they have significant side effects. This is a case report of a 27-year-old woman with ITP who was found to be anemic, thrombocytopenic, and had a ruptured ovarian cyst after the initial romiplostim therapy. The patient benefited from fluid resuscitation, blood transfusion, and corticosteroid therapy; then, the patient's condition improved. This case highlights the complications associated with managing ITP, emphasizing the importance of personalizing therapy regimens through regular monitoring to improve the balance of benefits and risk, resulting in a comprehensive treatment for chronic patients suffering from ITP.
特发性血小板减少性紫癜（ITP）的特征是血小板计数持续偏低，这可能导致严重出血，如胃炎和出血性中风。ITP中自身抗体的形成会导致血小板破坏增加，进而阻碍造血。皮质类固醇和静脉注射免疫球蛋白是治疗ITP的常用方法，但它们有显著的副作用。这是一例27岁ITP女性患者的病例报告，该患者在初始使用罗米司亭治疗后出现贫血、血小板减少，并伴有卵巢囊肿破裂。患者通过液体复苏、输血和皮质类固醇治疗获益，随后病情好转。该病例突出了管理ITP相关的并发症，强调了通过定期监测来个性化治疗方案以改善获益与风险平衡的重要性，从而为患有ITP的慢性病患者提供全面治疗。
