Farooqi Palwasha, Yaqobi Adila, Mia Khail Bushra, Niño Medina Jose A, Obaid Ullah Zainab, Saeed Abed, Alamy Haroon, Farooqi Syed Ahmad, Azizi Najim, Duarte Leonor E, Ghani Torgot, Aminpoor Hasibullah
Internal Medicine, Kabul University of Medical Sciences, Kabul, AFG.
Pediatric Medicine, Kabul University of Medical Sciences, Kabul, AFG.
Cureus. 2024 Jul 10;16(7):e64245. doi: 10.7759/cureus.64245. eCollection 2024 Jul.
Over 20% of ischemic strokes are cardioembolic strokes, necessitating research into thrombus formation locations, particularly the left atrial appendage (LAA). The left atrial septal pouch (LASP), which is linked to thrombus development and stasis, has drawn attention recently as a possible thromboembolic location, especially in atrial fibrillation (AF). The primary aim of this review is to explore LASP's role in cryptogenic strokes and to discuss the methods used to assess LAA anatomy. Imaging modalities such as cardiac computed tomography (CT) and transesophageal echocardiography (TEE) are crucial for diagnosing and characterizing LASP. LASP, found in about one-third of individuals, provides an additional site for thrombus development in the left atrium. The potential clinical implications of LASP-related thromboembolic events include the need for targeted therapeutic strategies, such as anticoagulant medication and, in some cases, consideration of LASP closure to prevent recurrent strokes. Further investigation is required to elucidate LASP's involvement in thromboembolic events and to guide stroke prevention in at-risk patients.
超过20%的缺血性中风是心源性栓塞性中风，因此有必要对血栓形成部位进行研究，特别是左心耳（LAA）。左房隔袋（LASP）与血栓形成和淤滞有关，最近作为一个可能的血栓栓塞部位受到关注，尤其是在心房颤动（AF）中。本综述的主要目的是探讨LASP在隐源性中风中的作用，并讨论评估LAA解剖结构的方法。心脏计算机断层扫描（CT）和经食管超声心动图（TEE）等成像方式对于诊断和表征LASP至关重要。LASP在约三分之一的个体中被发现，为左心房血栓形成提供了一个额外的部位。LASP相关血栓栓塞事件的潜在临床意义包括需要有针对性的治疗策略，如抗凝药物治疗，在某些情况下，考虑封闭LASP以预防中风复发。需要进一步研究以阐明LASP在血栓栓塞事件中的作用，并指导高危患者的中风预防。
