Balaji Nivedha, Ignatowicz Aleksandra, Kalra Aarushi, Mansour Rami, Jadhav Vaishali
Internal Medicine, Northeast Georgia Medical Center Gainsville, Gainesville, USA.
Internal Medicine, Philadelphia College of Osteopathic Medicine, Suwanee, USA.
Cureus. 2024 Jul 11;16(7):e64317. doi: 10.7759/cureus.64317. eCollection 2024 Jul.
Autoimmune encephalitis (AE) is a rare immune-mediated disorder comprised of non-infectious neuroinflammatory disease processes. Clinical presentation overlaps with a broad range of neurodegenerative disorders and infectious encephalitis; therefore, AE remains a diagnosis of exclusion. Patients may present with nonspecific symptoms such as psychiatric disturbances, cognitive deficits, seizures, movement disorders, and confusion. Prompt diagnosis and management are necessary for patients with AE to decrease mortality and improve quality of life. First-line therapy includes immunosuppression with corticosteroids, intravenous immunoglobulin, and plasmapheresis. We report the case of an 86-year-old female with a medical history of Parkinson's disease who presented with nonspecific seizure-like activity and was diagnosed with AE.
自身免疫性脑炎（AE）是一种罕见的免疫介导性疾病，由非感染性神经炎症性疾病过程组成。其临床表现与多种神经退行性疾病和感染性脑炎重叠；因此，AE仍然是一种排除性诊断。患者可能出现非特异性症状，如精神障碍、认知缺陷、癫痫发作、运动障碍和意识模糊。对于AE患者，及时诊断和治疗对于降低死亡率和提高生活质量至关重要。一线治疗包括使用皮质类固醇、静脉注射免疫球蛋白和血浆置换进行免疫抑制。我们报告了一例86岁女性患者，有帕金森病病史，出现非特异性癫痫样活动，被诊断为AE。
