Paolilo Renata Barbosa, Deiva Kumaran, Neuteboom Rinze, Rostásy Kevin, Lim Ming
Department of Neurology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo (HCFMUSP), São Paulo 05508-060, Brazil.
Department of Pediatric Neurology, Assistance Publique-Hôpitaux de Paris, University Hospitals Paris Saclay, Bicêtre Hospital, 72, Rue G Leclerc, 94270 Le Kremlin Bicêtre, France.
Children (Basel). 2020 Nov 3;7(11):210. doi: 10.3390/children7110210.
Acute disseminated encephalomyelitis (ADEM) is an immune-mediated central nervous system (CNS) disorder, characterized by polyfocal symptoms, encephalopathy and typical magnetic resonance imaging (MRI) findings, that especially affects young children. Advances in understanding CNS neuroimmune disorders as well as the association of myelin oligodendrocyte glycoprotein antibody (MOG-Ab) with both monophasic and recurrent forms of ADEM have led to new insights into its definition, management and outcome. In this review, we aim to provide an update based on current epidemiologic, clinical, radiological and immunopathological aspects and clinical outcome of ADEM.
急性播散性脑脊髓炎（ADEM）是一种免疫介导的中枢神经系统（CNS）疾病，其特征为多灶性症状、脑病及典型的磁共振成像（MRI）表现，尤其好发于儿童。随着对中枢神经系统神经免疫性疾病认识的进展，以及髓鞘少突胶质细胞糖蛋白抗体（MOG-Ab）与单相及复发型ADEM的关联，人们对其定义、管理及预后有了新的认识。在本综述中，我们旨在基于当前的流行病学、临床、放射学及免疫病理学方面以及ADEM的临床结局提供最新信息。
