Shi Ruizi, Wang Yihui, Chen Ying, Yang Zhitao, Jing Feng, Shang Hanbing, Chen Erzhen, Zhou Ying
Shanghai Institute of Aviation Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Neurol. 2024 Jul 26;15:1420898. doi: 10.3389/fneur.2024.1420898. eCollection 2024.
Fangcang shelter hospitals are quarantine facilities offering primary medical treatment for mild and asymptomatic SARS-CoV-2 cases. Little is known about the age-specific prevalence of insomnia among patients in Fangcang shelter hospitals, particularly in older age groups.
This cross-sectional study was conducted in the three largest Fangcang shelter hospitals during the lockdown period, from March to May 2022, in Shanghai. The patients' demographic and medical information was recorded. Insomnia was defined according to the prescriptions for zolpidem and estazolam. The overall and age-specific prevalence and the risk factors of insomnia were investigated through regression models.
A total of 2,39,448 patients were included in this study (59.09% of the patients were male, the median age was 42, and 73.41% of the patients were asymptomatic), with the prevalence of insomnia being 3.1%. The prevalence of insomnia varied across different age groups (<18 years: 0.23%, 18-64 years: 2.64%, and ≥65 years: 10.36%). SARS-CoV-2 vaccine, regardless of the number of doses, was significantly associated with a decreased risk of insomnia for the group aged ≥65 years. Three doses of the vaccine reduced the risk of insomnia for patients aged 18-64 years. An extra day in the hospital significantly increased the risk of insomnia by approximately 10% for all age groups. Mild symptoms were significantly associated with a higher risk of insomnia among patients aged <65 years old, while being male and residing in the surrounding area were negatively associated with insomnia for all adults.
This study observed that older patients were a high-risk population for developing insomnia in Fangcang shelter hospitals. SARS-CoV-2 vaccination might decrease the risk of insomnia in adults, especially the older adult, which indicates the benefits of vaccination for reducing insomnia among infected patients.
方舱医院是为新型冠状病毒肺炎轻症和无症状感染者提供基本医疗服务的隔离设施。目前对于方舱医院患者中失眠症的年龄特异性患病率知之甚少，尤其是在老年人群体中。
本横断面研究于2022年3月至5月上海封控期间在三家最大的方舱医院开展。记录患者的人口统计学和医疗信息。根据唑吡坦和艾司唑仑的处方定义失眠症。通过回归模型研究失眠症的总体患病率、年龄特异性患病率及其危险因素。
本研究共纳入239448例患者（59.09%为男性，中位年龄为42岁，73.41%为无症状感染者），失眠症患病率为3.1%。失眠症患病率在不同年龄组中有所不同（<18岁：0.23%，18 - 64岁：2.64%，≥65岁：10.36%）。无论接种剂量如何，新型冠状病毒疫苗与≥65岁年龄组失眠风险降低显著相关。接种三剂疫苗可降低18 - 64岁患者的失眠风险。住院时间每增加一天，所有年龄组的失眠风险显著增加约10%。轻症与<65岁患者中较高的失眠风险显著相关，而男性和居住在周边地区与所有成年人的失眠呈负相关。
本研究观察到老年患者是方舱医院中发生失眠症的高危人群。接种新型冠状病毒疫苗可能会降低成年人尤其是老年人的失眠风险，这表明接种疫苗对于降低感染患者的失眠症有益。
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