安卓系统（ANDROID）和白蛋白/球蛋白比值（A/G ratio）与2型糖尿病患者的肌肉减少症相关。
ANDROID and A/G ratio are correlated with sarcopenia among type 2 diabetes patients.
作者信息
Zhang Dongxiao, Li Chen, Hu Wenchao, He Lanjie
机构信息
Department of Endocrinology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, China.
Department of Endocrinology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Shibei District, Qingdao 266035, Shandong, China.
出版信息
Ther Adv Endocrinol Metab. 2024 Aug 7;15:20420188241269181. doi: 10.1177/20420188241269181. eCollection 2024.
BACKGROUND
Fat distribution plays an important role in impaired glucose tolerance. Android adiposity (ANDROID) and gynoid adiposity (GYNOID) have been proven to be linked with insulin resistance. A higher risk of sarcopenia is associated with type 2 diabetes mellitus (T2DM). In this study, ANDROID, GYNOID, and ANDROID to GYNOID ratios (A/G ratios) were evaluated in T2DM patients to determine if they were associated with sarcopenia.
METHODS
We recruited 1086 T2DM patients, measured skeletal muscle index (SMI), ANDROID, GYNOID, and collected clinical data.
RESULTS
T2DM patients with 119 male subjects had sarcopenia (20.24%), and 72 female subjects had sarcopenia (16.51%). All patients with T2DM who had high ANDROID and A/G ratios were at a reduced risk of sarcopenia. The SMI showed a correlation with ANDROID and A/G ratios among subjects with T2DM.
CONCLUSION
ANDROID and A/G ratios are inversely related to sarcopenia in T2DM patients.
背景
脂肪分布在糖耐量受损中起重要作用。已证实腹型肥胖（ANDROID）和臀型肥胖（GYNOID）与胰岛素抵抗有关。2型糖尿病（T2DM）患者发生肌肉减少症的风险更高。在本研究中，对T2DM患者的ANDROID、GYNOID以及ANDROID与GYNOID比值（A/G比值）进行评估，以确定它们是否与肌肉减少症相关。
方法
我们招募了1086例T2DM患者，测量骨骼肌指数（SMI）、ANDROID、GYNOID，并收集临床数据。
结果
119例男性T2DM患者存在肌肉减少症（20.24%），72例女性患者存在肌肉减少症（16.51%）。所有ANDROID和A/G比值高的T2DM患者发生肌肉减少症的风险降低。在T2DM患者中，SMI与ANDROID和A/G比值相关。
结论
在T2DM患者中，ANDROID和A/G比值与肌肉减少症呈负相关。
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