Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
Malaysian Research Institute on Ageing, Universiti Putra Malaysia, Serdang, Malaysia.
PLoS One. 2020 May 20;15(5):e0233299. doi: 10.1371/journal.pone.0233299. eCollection 2020.
Sarcopenia is a recognised geriatric syndrome but few studies address its associated factors among elderly with type 2 diabetes mellitus (T2DM) in South East Asia. This study aimed to determine the prevalence of sarcopenia and its associated factors among the elderly with T2DM in public primary care clinics in Malaysia. This study utilised data from a longitudinal study of 506 adults with T2DM aged ≥60 years. Data on socio-demography, clinical and functional status, diet and levels of physical activity (PA) were collected. Sarcopenia was defined using Asian Working Group for Sarcopenia criteria and its associated factors were analysed using multiple logistic regression. The proportion of elderly with T2DM with sarcopenia was 28.5%. Those aged ≥70 years (β = 0.73;OR = 2.07; 95%CI = 1.24, 3.48; p = 0.006), men (β = 0.61; OR = 1.84; 95%CI = 1.12, 3.02; p = 0.017), with ≥10 years duration of diabetes (β = 0.62; OR = 1.85; 95%CI = 1.11, 3.09; p = 0.018), not using insulin sensitizers (β = -1.44; OR = 0.24; 95%CI = 0.08, 0.71; p = 0.010), using less than 5 medications (β = 0.68; OR = 1.98; 95%CI = 1.17, 3.36; p = 0.011), low body mass index (BMI) (β = -2.43; OR = 0.09; 95%CI = 0.05, 0.17; p<0.001), and engaging in low (β = 0.77; OR = 2.15; 95%CI = 1.07, 4.35; p = 0.032) and moderate physical activities (β = 0.80; OR = 2.23; 95%CI = 1.07, 4.66; p = 0.033) were associated with sarcopenia. Factors that predicts sarcopenia such as level of physical activity and body mass index were among the modifiable factors that could be used in developing future strategies to prevent or delay the progression of sarcopenia among elderly with T2DM to improve their health status.
肌少症是一种公认的老年综合征，但在东南亚，很少有研究关注 2 型糖尿病（T2DM）老年患者的相关因素。本研究旨在确定马来西亚公立初级保健诊所中 T2DM 老年患者肌少症的患病率及其相关因素。本研究利用了一项针对 506 名年龄≥60 岁的 T2DM 成年人的纵向研究的数据。收集了社会人口统计学、临床和功能状态、饮食和身体活动（PA）水平的数据。使用亚洲肌少症工作组标准定义肌少症，并使用多因素逻辑回归分析其相关因素。患有 T2DM 的老年患者中肌少症的比例为 28.5%。年龄≥70 岁（β=0.73；OR=2.07；95%CI=1.24，3.48；p=0.006）、男性（β=0.61；OR=1.84；95%CI=1.12，3.02；p=0.017）、糖尿病病程≥10 年（β=0.62；OR=1.85；95%CI=1.11，3.09；p=0.018）、未使用胰岛素增敏剂（β=-1.44；OR=0.24；95%CI=0.08，0.71；p=0.010）、使用少于 5 种药物（β=0.68；OR=1.98；95%CI=1.17，3.36；p=0.011）、低体重指数（BMI）（β=-2.43；OR=0.09；95%CI=0.05，0.17；p<0.001）和进行低（β=0.77；OR=2.15；95%CI=1.07，4.35；p=0.032）和中度体力活动（β=0.80；OR=2.23；95%CI=1.07，4.66；p=0.033）与肌少症相关。身体活动水平和体重指数等预测肌少症的因素是可用于制定未来策略的可改变因素之一，这些策略可用于预防或延缓 T2DM 老年患者肌少症的进展，以改善他们的健康状况。
