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腰围与慢性疼痛之间的关联：来自观察性研究和两样本孟德尔随机化的见解

Association between waist circumference and chronic pain: insights from observational study and two-sample Mendelian randomization.

作者信息

Xu Ting, Jin Fan, Yu Yeting, He Jie, Yang Ren, Lv Tian, Yan Zhangjun

机构信息

Department of Anesthesiology, Traditional Chinese Medical Hospital of Zhuji, Zhuji, China.

Department of Anesthesiology, Zhuji People's Hospital, Shaoxing University, Zhuji, China.

出版信息

Front Nutr. 2024 Jul 26;11:1415208. doi: 10.3389/fnut.2024.1415208. eCollection 2024.

DOI:10.3389/fnut.2024.1415208
PMID:39131735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11310123/
Abstract

BACKGROUND

Current research offers limited clarity on the correlation between waist circumference and chronic pain prevalence.

OBJECTIVE

This investigation seeks to elucidate the potential relationship between waist circumference and chronic pain and their causal association.

METHODS

An observational study was conducted, leveraging data from the National Health and Nutrition Examination Survey (NHANES) collected between 2001 and 2004. The multivariable logistic regression was used to assess the relationship between waist circumference and chronic pain. Furthermore, a meta-analysis of Mendelian Randomization (MR) was applied to explore a causal relationship between waist circumference and pain.

RESULTS

The observational study, post multivariable adjustment, indicated that an increase in waist circumference by 1 dm (decimeter) correlates with a 14% elevation in chronic pain risk (Odds Ratio [OR] = 1.14, 95% Confidence Interval [CI]: 1.04-1.24,  = 0.01). Moreover, the meta-analysis of MR demonstrated that an increased waist circumference was associated with a genetic predisposition to pain risk (OR = 1.14, 95%CI: 1.06-1.23, = 0.0007).

CONCLUSION

Observational analysis confirmed a significant relationship between increased waist circumference and the incidence of chronic pain, and results based on MR Study identified increased waist circumference as potentially causal for pain.

摘要

背景

目前的研究对腰围与慢性疼痛患病率之间的相关性阐释有限。

目的

本调查旨在阐明腰围与慢性疼痛之间的潜在关系及其因果关联。

方法

进行了一项观察性研究，利用2001年至2004年期间收集的美国国家健康与营养检查调查（NHANES）的数据。采用多变量逻辑回归评估腰围与慢性疼痛之间的关系。此外，应用孟德尔随机化（MR）的荟萃分析来探讨腰围与疼痛之间的因果关系。

结果

多变量调整后的观察性研究表明，腰围每增加1分米（dm），慢性疼痛风险升高14%（优势比[OR]=1.14，95%置信区间[CI]：1.04-1.24，P=0.01）。此外，MR的荟萃分析表明，腰围增加与疼痛风险的遗传易感性相关（OR=1.14，95%CI：1.06-1.23，P=0.0007）。

结论

观察性分析证实腰围增加与慢性疼痛发生率之间存在显著关系，基于MR研究的结果确定腰围增加可能是疼痛的病因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8000/11310123/c70771f97cf9/fnut-11-1415208-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8000/11310123/38500184a935/fnut-11-1415208-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8000/11310123/b19a521c4fb7/fnut-11-1415208-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8000/11310123/d6a2fcb045ba/fnut-11-1415208-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8000/11310123/c70771f97cf9/fnut-11-1415208-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8000/11310123/38500184a935/fnut-11-1415208-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8000/11310123/b19a521c4fb7/fnut-11-1415208-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8000/11310123/d6a2fcb045ba/fnut-11-1415208-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8000/11310123/c70771f97cf9/fnut-11-1415208-g004.jpg

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