Liu Wei, Li Chunyan, Xie Wenhui, Fan Yong, Zhang Xiaohui, Wang Yu, Li Lei, Zhang Zhuoli
Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing, China.
Department of Clinical Laboratory, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.
Ther Adv Musculoskelet Dis. 2024 Aug 10;16:1759720X241266720. doi: 10.1177/1759720X241266720. eCollection 2024.
Gut microbiota is involved in the development of psoriatic arthritis (PsA), but until now, there has been a lack of understanding of the PsA host-bacteria interaction.
To reveal the labels of gut microbiota in PsA patients and the species and functions related to disease activity.
Observational research (cross-sectional) with an exploratory nature.
Metagenomics sequencing was used to analyze stool samples from 20 treatment-naïve PsA patients and 10 age-matched healthy individuals. All samples were qualified for subsequent analysis.
Compared with the healthy group, α-diversity was reduced in the PsA group, and β-diversity could distinguish the two groups. Two bacteria with high abundance and correlation with PsA disease activity were identified, and . In different functions, K07114 (calcium-activated chloride channel (CaCC) homolog) showed a positive correlation with PsA disease activity (disease activity in psoriatic arthritis, DAPSA) and Tet32 (an antibiotic-resistant gene), and carbohydrate-binding module family 50 was negatively correlated with erythrocyte sedimentation rate. A bacterial co-expression network associated with DAPSA was constructed. The network was centered on the bacteria in the genus, which formed a closely related network and were positively correlated with DAPSA. As another core of the network, K07114 was closely related to multiple bacteria in the genus and is also positively correlated with disease activity.
The network composed of is associated with PsA disease activity, and its therapeutic value needs to be further explored. CaCCs may be a key channel for the interaction between and PsA-host.
肠道微生物群参与银屑病关节炎（PsA）的发病过程，但迄今为止，人们对PsA宿主与细菌之间的相互作用仍缺乏了解。
揭示PsA患者肠道微生物群的特征以及与疾病活动相关的种类和功能。
具有探索性的观察性研究（横断面研究）。
采用宏基因组测序分析20例未经治疗的PsA患者和10例年龄匹配的健康个体的粪便样本。所有样本均符合后续分析要求。
与健康组相比，PsA组的α多样性降低，β多样性可区分两组。鉴定出两种与PsA疾病活动度具有高丰度和相关性的细菌，分别为 和 。在不同功能中，K07114（钙激活氯离子通道（CaCC）同源物）与PsA疾病活动度（银屑病关节炎疾病活动度，DAPSA）呈正相关，Tet32（一种抗生素抗性基因）以及碳水化合物结合模块家族50与红细胞沉降率呈负相关。构建了一个与DAPSA相关的细菌共表达网络。该网络以 属细菌为中心，它们形成了一个紧密相关的网络，且与DAPSA呈正相关。作为网络的另一个核心，K07114与 属中的多种细菌密切相关，并且也与疾病活动度呈正相关。
由 组成的网络与PsA疾病活动度相关，其治疗价值有待进一步探索。CaCCs可能是 与PsA宿主之间相互作用的关键通道。
