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角膜炎:一种具有成功治疗结果的临床诊断。

keratitis: A clinical diagnosis with successful outcome.

作者信息

Srujana Dubbaka, Shankar Sandeep, Anand Kavita Bala, Agrawal Mohini, Singhal Aanchal, Kumar Ashok, Kochhar Divya

机构信息

Department of Ophthalmology, Armed Forces Medical College, Pune, Maharashtra, India.

Department of Microbiology, Armed Forces Medical College, Pune, Maharashtra, India.

出版信息

Oman J Ophthalmol. 2024 Jun 27;17(2):261-263. doi: 10.4103/ojo.ojo_175_23. eCollection 2024 May-Aug.

DOI:10.4103/ojo.ojo_175_23
PMID:39132098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11309550/
Abstract

keratitis is mostly seen in patients with alcoholism, malnutrition, or HIV. Its chronic waxing-and-waning course makes it difficult to diagnose. A 53-year-old male presented with pain and redness in his right eye for the past 3 weeks. The cornea had paracentral ulcer with stromal infiltrates and multiple satellite lesions giving wreath-like appearance suggestive of . After corneal scraping, fortified amikacin, moxifloxacin, and cycloplegics were started. Gram stain revealed filamentous, branching Gram-positive bacteria and acid-fast on Ziehl-Neelsen stain confirming our clinical diagnosis. Ulcer completely resolved over 6 weeks. Thus, a high index of clinical suspicion which was further backed by microbiological confirmation aided in expedient management ensuring a successful outcome.

摘要

角膜炎多见于酗酒、营养不良或感染艾滋病毒的患者。其慢性的病情反复过程使得诊断困难。一名53岁男性在过去3周出现右眼疼痛和发红。角膜有旁中心溃疡伴基质浸润和多个卫星病灶,呈花环样外观,提示……角膜刮片后,开始使用强化阿米卡星、莫西沙星和睫状肌麻痹剂。革兰氏染色显示丝状、分支的革兰氏阳性菌,齐-尼氏染色显示抗酸菌,从而证实了我们的临床诊断。溃疡在6周内完全愈合。因此,高度的临床怀疑加上微生物学确认的支持有助于进行有效的治疗,确保取得成功的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a0/11309550/85313eab6f2e/OJO-17-261-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a0/11309550/6d3220532dfa/OJO-17-261-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a0/11309550/85313eab6f2e/OJO-17-261-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a0/11309550/6d3220532dfa/OJO-17-261-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a0/11309550/85313eab6f2e/OJO-17-261-g002.jpg

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本文引用的文献

1
Bilateral nocardia keratitis after photorefractive keratectomy.准分子激光原位角膜磨镶术后双侧诺卡菌性角膜炎
J Ophthalmic Vis Res. 2012 Apr;7(2):162-6.
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Fungal, Mycobacterial, and Nocardia infections and the eye: an update.真菌、分枝杆菌和奴卡菌感染与眼睛:最新进展。
Eye (Lond). 2012 Feb;26(2):245-51. doi: 10.1038/eye.2011.332. Epub 2011 Dec 16.
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Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT).用于细菌性角膜炎的皮质类固醇:角膜溃疡类固醇试验(SCUT)。
Arch Ophthalmol. 2012 Feb;130(2):143-50. doi: 10.1001/archophthalmol.2011.315. Epub 2011 Oct 10.
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Ophthalmology. 2011 Jun;118(6):1193-200. doi: 10.1016/j.ophtha.2010.10.037. Epub 2011 Jan 26.
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Nocardia keratitis.诺卡菌性角膜炎
Curr Opin Ophthalmol. 2009 Jul;20(4):318-23. doi: 10.1097/ICU.0b013e32832c3bcc.
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Outbreak of Nocardia keratitis after photorefractive keratectomy: clinical, microbiological, histopathological, and confocal scan study.准分子激光角膜切削术后诺卡菌性角膜炎暴发:临床、微生物学、组织病理学及共焦扫描研究
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Nocardia asteroides keratitis in south India.
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Efficacy of topical and systemic itraconazole as a broad-spectrum antifungal agent in mycotic corneal ulcer. A preliminary study.局部及全身应用伊曲康唑作为广谱抗真菌药治疗真菌性角膜溃疡的疗效:一项初步研究
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