哈桑·萨迪金淋巴瘤登记处淋巴瘤患者的临床和生物标志物特征
Clinical and Biomarker Characteristic of Lymphoma Patients in Hasan Sadikin Lymphoma Registry.
作者信息
Oehadian Amaylia, Kartikasari Andini, Mersiana Lusi, Gunadi Stephanie Victoria, Fungani Gusti, Vidyaniati Putri, Prasetya Dimmy, Wijaya Indra, Fianza Pandji Irani, Fadjari Trinugroho Heri, Sutedjo Nanny Natalia
机构信息
Division of Hematology and Oncology Medic, Internal Medicine Department, Faculty of Medicine, Padjadjaran University/ Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
Bandung City Regional General Hospital, Bandung, Indonesia.
出版信息
J Blood Med. 2024 Aug 5;15:341-349. doi: 10.2147/JBM.S472791. eCollection 2024.
BACKGROUND
No specific data have been systematically collected regarding lymphoma patient characteristics, while non-Hodgkin lymphoma (NHL) is identified as the 7 most common cancer and Hodgkin lymphoma (HL) is the 28. Inflammation plays an important role in the pathogenesis and progression of lymphoma. Malnutrition is an adverse prognostic factor in lymphoma. Systemic Inflammatory Index (SII), Prognostic Nutritional Index (PNI), and Advanced Lung Cancer Inflammation Index (ALI) were biomarkers depicting inflammation and nutritional status. This study aims to describe the clinical and biomarker characteristics of both HL and NHL patients.
METHODS
This descriptive study used a cross-sectional design, and data were collected from Hasan Sadikin Hospital lymphoma registry from January 2020 to November 2023. Demographic, staging, and histopathological data were extracted. Three biomarkers were evaluated. Survival curves were drawn using Kaplan-Meier curve analysis, and the log rank test was used for comparison of survival between early and advanced stage.
RESULTS
A total of 271 patients were recruited as participants, and the majority (80.5%) had NHL, with diffuse large B-cell lymphoma (DLBCL) being the most common histopathological type (50.5%). Early disease was observed in two-thirds of patients, and low-risk International Prognostic Index (IPI) score was the most common prognostic score found (95%). SII was slightly higher in early compared to advanced stages. Treatment response was evaluated from 101 patients, and complete response was observed in 44.5%. Two-year overall survival (OS) was 93.1%, with median survival 22.7 (95% CI 21.9-23.5) months. In early stage, the median survival was slightly longer than in advanced stage [23.0 (95% CI 22.2-23.8) vs 21.6 (95% CI 19.3-23.8) months, 0.09].
CONCLUSION
Hodgkin lymphoma and DLBCL had similar clinical and biomarker characteristics. There were slight differences between the three biomarkers SII, ALI, and PNI based on the disease stage. Almost all patients still survived at 2-year follow-up.
背景
目前尚未系统收集有关淋巴瘤患者特征的具体数据，非霍奇金淋巴瘤（NHL）被确定为第七大常见癌症，霍奇金淋巴瘤（HL）为第二十八位。炎症在淋巴瘤的发病机制和进展中起重要作用。营养不良是淋巴瘤的不良预后因素。全身炎症指数（SII）、预后营养指数（PNI）和晚期肺癌炎症指数（ALI）是描述炎症和营养状况的生物标志物。本研究旨在描述HL和NHL患者的临床和生物标志物特征。
方法
本描述性研究采用横断面设计，数据收集自2020年1月至2023年11月哈桑·萨迪金医院淋巴瘤登记处。提取人口统计学、分期和组织病理学数据。评估三种生物标志物。使用Kaplan-Meier曲线分析绘制生存曲线，并使用对数秩检验比较早期和晚期的生存率。
结果
共招募了271名患者作为参与者，大多数（80.5%）患有NHL其中弥漫性大B细胞淋巴瘤（DLBCL）是最常见的组织病理学类型（50.5%）。三分之二的患者为疾病早期，低风险国际预后指数（IPI）评分是最常见的预后评分（95%）。早期的SII略高于晚期。对101名患者评估了治疗反应，44.5%观察到完全缓解。两年总生存率（OS）为93.1%，中位生存期为22.
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